Quick Search:

uzh logo
Browse by:
bullet
bullet
bullet
bullet

Zurich Open Repository and Archive

Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-53203

de Arteaga, J; Ledesma, F; Garay, G; Chiurchiu, C; de la Fuente, J; Douthat, W; Massari, P; Terryn, S; Devuyst, O (2011). High-dose steroid treatment increases free water transport in peritoneal dialysis patients. Nephrology, Dialysis, Transplantation, 26(12):4142-4145.

[img]
Preview
Accepted Version
PDF
406kB

View at publisher

Abstract

The water channel aquaporin-1 (AQP1) is the molecular counterpart of the ultrasmall pore that mediates free water transport during peritoneal dialysis (PD). Proof-of-principle studies performed in rats have shown that treatment with corticosteroids upregulates the expression of AQP1 in the peritoneal capillaries, causing a significant increase in free water transport. Whether such a beneficial effect could be observed in end-stage renal disease patients treated by PD remains unknown. Peritoneal transport parameters were evaluated in three patients on PD, shortly before and after living-donor renal transplantation and treatment with high-dose methylprednisolone (1.0-1.2 g/m(2)). As compared with pre-transplantation values, the post-transplantation test revealed an ∼2-fold increase in the sodium sieving and ultrasmall pore ultrafiltration volume, suggesting an effect on AQP1 water channels. In contrast, there was no change in the parameters of small solute transport. The direct involvement of AQP1 in these changes is suggested by the expression of glucocorticoid receptors in the human peritoneum and the presence of conserved glucocorticoid response elements in the promoter of the human AQP1 gene.

Citations

3 citations in Web of Science®
4 citations in Scopus®
Google Scholar™

Altmetrics

Downloads

24 downloads since deposited on 11 Jan 2012
11 downloads since 12 months

Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Physiology
07 Faculty of Science > Institute of Physiology

04 Faculty of Medicine > Center for Integrative Human Physiology
DDC:570 Life sciences; biology
610 Medicine & health
Language:English
Date:2011
Deposited On:11 Jan 2012 11:44
Last Modified:03 Dec 2013 10:06
Publisher:Oxford University Press
ISSN:0931-0509
Additional Information:This is a pre-copy-editing, author-produced PDF of an article accepted for publication in Nephrology Dialysis Transplantation following peer review. The definitive publisher-authenticated version de Arteaga, J; Ledesma, F; Garay, G; Chiurchiu, C; de la Fuente, J; Douthat, W; Massari, P; Terryn, S; Devuyst, O (2011). High-dose steroid treatment increases free water transport in peritoneal dialysis patients. Nephrology Dialysis Transplantation, 26(12):4142-4145 is available online at: http://ndt.oxfordjournals.org/content/26/12/4142.long
Publisher DOI:10.1093/ndt/gfr533
PubMed ID:21940485

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page