Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-53203
de Arteaga, J; Ledesma, F; Garay, G; Chiurchiu, C; de la Fuente, J; Douthat, W; Massari, P; Terryn, S; Devuyst, O (2011). High-dose steroid treatment increases free water transport in peritoneal dialysis patients. Nephrology, Dialysis, Transplantation, 26(12):4142-4145.
The water channel aquaporin-1 (AQP1) is the molecular counterpart of the ultrasmall pore that mediates free water transport during peritoneal dialysis (PD). Proof-of-principle studies performed in rats have shown that treatment with corticosteroids upregulates the expression of AQP1 in the peritoneal capillaries, causing a significant increase in free water transport. Whether such a beneficial effect could be observed in end-stage renal disease patients treated by PD remains unknown. Peritoneal transport parameters were evaluated in three patients on PD, shortly before and after living-donor renal transplantation and treatment with high-dose methylprednisolone (1.0-1.2 g/m(2)). As compared with pre-transplantation values, the post-transplantation test revealed an ∼2-fold increase in the sodium sieving and ultrasmall pore ultrafiltration volume, suggesting an effect on AQP1 water channels. In contrast, there was no change in the parameters of small solute transport. The direct involvement of AQP1 in these changes is suggested by the expression of glucocorticoid receptors in the human peritoneum and the presence of conserved glucocorticoid response elements in the promoter of the human AQP1 gene.
|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||04 Faculty of Medicine > Institute of Physiology|
07 Faculty of Science > Institute of Physiology
04 Faculty of Medicine > Center for Integrative Human Physiology
|DDC:||570 Life sciences; biology|
610 Medicine & health
|Deposited On:||11 Jan 2012 12:44|
|Last Modified:||09 Dec 2012 17:58|
|Publisher:||Oxford University Press|
|Additional Information:||This is a pre-copy-editing, author-produced PDF of an article accepted for publication in Nephrology Dialysis Transplantation following peer review. The definitive publisher-authenticated version de Arteaga, J; Ledesma, F; Garay, G; Chiurchiu, C; de la Fuente, J; Douthat, W; Massari, P; Terryn, S; Devuyst, O (2011). High-dose steroid treatment increases free water transport in peritoneal dialysis patients. Nephrology Dialysis Transplantation, 26(12):4142-4145 is available online at: http://ndt.oxfordjournals.org/content/26/12/4142.long|
|WoS Citation Count:||0|
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