Quick Search:

uzh logo
Browse by:

Zurich Open Repository and Archive

Maintenance: Tuesday, July the 26th 2016, 07:00-10:00

ZORA's new graphical user interface will be relaunched (For further infos watch out slideshow ZORA: Neues Look & Feel). There will be short interrupts on ZORA Service between 07:00am and 10:00 am. Please be patient.

Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-53530

Pagani, L; Schmitt, K; Meier, F; Izakovic, J; Roemer, K; Viola, A; Cajochen, C; Wirz-Justice, A; Brown, S A; Eckert, A (2011). Serum factors in older individuals change cellular clock properties. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 108(17):7218-7223.

[img]Published Version
PDF - Registered users only
View at publisher


Human aging is accompanied by dramatic changes in daily sleep-wake behavior: Activity shifts to an earlier phase, and the consolidation of sleep and wake is disturbed. Although this daily circadian rhythm is brain-controlled, its mechanism is encoded by cell-autonomous circadian clocks functioning in nearly every cell of the body. In fact, human clock properties measured in peripheral cells such as fibroblasts closely mimic those measured physiologically and behaviorally in the same subjects. To understand better the molecular mechanisms by which human aging affects circadian clocks, we characterized the clock properties of fibroblasts cultivated from dermal biopsies of young and older subjects. Fibroblast period length, amplitude, and phase were identical in the two groups even though behavior was not, thereby suggesting that basic clock properties of peripheral cells do not change during aging. Interestingly, measurement of the same cells in the presence of human serum from older donors shortened period length and advanced the phase of cellular circadian rhythms compared with treatment with serum from young subjects, indicating that a circulating factor might alter human chronotype. Further experiments demonstrated that this effect is caused by a thermolabile factor present in serum of older individuals. Thus, even though the molecular machinery of peripheral circadian clocks does not change with age, some age-related circadian dysfunction observed in vivo might be of hormonal origin and therefore might be pharmacologically remediable.


28 citations in Web of Science®
36 citations in Scopus®
Google Scholar™



2 downloads since deposited on 13 Jan 2012
0 downloads since 12 months

Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Pharmacology and Toxicology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Deposited On:13 Jan 2012 10:25
Last Modified:05 Apr 2016 15:16
Publisher:National Academy of Sciences
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:10.1073/pnas.1008882108
PubMed ID:21482780

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page