Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-53541
Bianda, Nicola; Di Valentino, Marcello; Périat, Daniel; Segatto, Jeanne Marie; Oberson, Michel; Moccetti, Marco; Sudano, Isabella; Santini, Paolo; Limoni, Costanzo; Froio, Alberto; Stuber, Matthias; Corti, Roberto; Gallino, Augusto; Wyttenbach, Rolf (2012). Progression of human carotid and femoral atherosclerosis: a prospective follow-up study by magnetic resonance vessel wall imaging. European Heart Journal, 33(2):230-237.
AimsThe time course of atherosclerosis burden in distinct vascular territories remains poorly understood. We longitudinally evaluated the natural history of atherosclerotic progression in two different arterial territories using high spatial resolution magnetic resonance imaging (HR-MRI), a powerful, safe, and non-invasive tool.Methods and resultsWe prospectively studied a cohort of 30 patients (mean age 68.3, n = 9 females) with high Framingham general cardiovascular disease 10-year risk score (29.5%) and standard medical therapy with mild-to-moderate atherosclerosis intra-individually at the level of both carotid and femoral arteries. A total of 178 HR-MRI studies of carotid and femoral arteries performed at baseline and at 1- and 2-year follow-up were evaluated in consensus reading by two experienced readers for lumen area (LA), total vessel area (TVA), vessel wall area (VWA = TVA - LA), and normalized wall area index (NWI = VWA/TVA). At the carotid level, LA decreased (-3.19%/year, P = 0.018), VWA increased (+3.83%/year, P = 0.019), and TVA remained unchanged. At the femoral level, LA remained unchanged, VWA and TVA increased (+5.23%/year and +3.11%/year, both P < 0.01), and NWI increased for both carotid and femoral arteries (+2.28%/year, P = 0.01, and +1.8%/year, P = 0.033).ConclusionThe atherosclerotic burden increased significantly in both carotid and femoral arteries. However, carotid plaque progression was associated with negative remodelling, whereas the increase in femoral plaque burden was compensated by positive remodelling. This finding could be related to anatomic and flow differences and/or to the distinct degree of obstruction in the two arterial territories.
|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||04 Faculty of Medicine > Center for Integrative Human Physiology|
04 Faculty of Medicine > University Hospital Zurich > Clinic for Cardiology
|DDC:||570 Life sciences; biology|
610 Medicine & health
|Deposited On:||05 Apr 2012 15:21|
|Last Modified:||23 Nov 2012 19:27|
|Publisher:||Oxford University Press|
|Additional Information:||This is a pre-copy-editing, author-produced PDF of an article accepted for publication in European Heart Journal following peer review. The definitive publisher-authenticated version Bianda, Nicola; Di Valentino, Marcello; Périat, Daniel; Segatto, Jeanne Marie; Oberson, Michel; Moccetti, Marco; Sudano, Isabella; Santini, Paolo; Limoni, Costanzo; Froio, Alberto; Stuber, Matthias; Corti, Roberto; Gallino, Augusto; Wyttenbach, Rolf (2012). Progression of human carotid and femoral atherosclerosis: a prospective follow-up study by magnetic resonance vessel wall imaging. European Heart Journal, 33(2):230-237 is available online at: http://eurheartj.oxfordjournals.org/content/33/2/230.|
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