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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-53675

Reid, J M; Arcese, P; Keller, L F (2003). Inbreeding depresses immune response in song sparrows (Melospiza melodia): direct and inter-generational effects. Proceedings of the Royal Society B: Biological Sciences, 270(1529):2151-2157.

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Abstract

A thorough knowledge of relationships between host genotype and immunity to parasitic infection is required to understand parasite-mediated mechanisms of genetic and population change. It has been suggested that immunity may decline with inbreeding. However, the relationship between inbreeding level and a host's response to a novel immune challenge has not been investigated in a natural population. We used the pedigreed population of song sparrows (Melospiza melodia) inhabiting Mandarte Island, Canada, to test the hypothesis that a sparrow's cell-mediated immune response (CMI) to an experimental challenge would decline with individual or parental inbreeding. CMI in 6-day-old chicks declined significantly with their mother's coefficient of inbreeding, demonstrating an inter-generational effect of maternal inbreeding on offspring immunity. In fledged juveniles and adult sparrows, CMI declined markedly with an individual's own coefficient of inbreeding, but not its mother's. This relationship was consistent across seasons, and was not attributable solely to heterosis in offspring of immigrant breeders. CMI also declined with age and increased with body condition in adult sparrows, but inbreeding explained 37% of the total variation. We emphasize the implications of this dramatic inbreeding depression in cell-mediated immunity for theories of parasite-mediated evolution and the susceptibility of small, inbred populations.

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Institute of Evolutionary Biology and Environmental Studies
DDC:570 Life sciences; biology
590 Animals (Zoology)
Language:English
Date:October 2003
Deposited On:30 Apr 2012 08:27
Last Modified:02 Dec 2013 08:07
Publisher:Royal Society of London
ISSN:0962-8452
Publisher DOI:10.1098/rspb.2003.2480
Other Identification Number:ISI:000186067000010
Citations:Web of Science®. Times Cited: 84
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Scopus®. Citation Count: 85

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