Quick Search:

uzh logo
Browse by:

Zurich Open Repository and Archive

Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-53783

Sand, P G; Langguth, B; Kleinjung, T (2011). Deep resequencing of the voltage-gated potassium channel subunit KCNE3 gene in chronic tinnitus. Behavioral and Brain Functions, 7:39.

View at publisher


Membrane-stabilizing drugs have long been used for the treatment of chronic tinnitus, suggesting an underlying disturbance of sensory excitability due to changes in ion conductance. The present study addresses the potassium channel subunit gene KCNE3 as a potential candidate for tinnitus susceptibility. 288 Caucasian outpatients with a diagnosis of chronic tinnitus were systematically screened for mutations in the KCNE3 open reading frame and in the adjacent region by direct sequencing. Allele frequencies were determined for 11 known variants of which two (F66F and R83H) were polymorphic but were not associated with the disorder. No novel variants were identified and only three carriers of R83H were noted. However, owing to a lack of power, our study can neither rule out effects of KCNE3 on the risk for developing chronic tinnitus, nor can it exclude a role in predicting the severity of tinnitus. More extensive investigations are invited, including tests for possible effects of variation in this ion channel protein on the response to treatment.


4 citations in Web of Science®
4 citations in Scopus®
Google Scholar™



29 downloads since deposited on 22 Dec 2011
15 downloads since 12 months

Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Otorhinolaryngology
Dewey Decimal Classification:610 Medicine & health
Deposited On:22 Dec 2011 14:29
Last Modified:05 Apr 2016 15:17
Publisher:BioMed Central
Free access at:Official URL. An embargo period may apply.
Publisher DOI:10.1186/1744-9081-7-39
Official URL:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3180252/
PubMed ID:21899751

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page