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Temporal changes in tissue cardiorespiratory function during faecal peritonitis


Dyson, A; Rudiger, A; Singer, M (2011). Temporal changes in tissue cardiorespiratory function during faecal peritonitis. Intensive Care Medicine, 37(7):1192-1200.

Abstract

This long-term septic model exhibited an early decline in tissue oxygenation, the degree of which related to predicted mortality. Clinical and biochemical deterioration, however, progressed despite cardiovascular recovery. Early circulatory dysfunction may thus be an important trigger for downstream processes that result in multi-organ failure. Furthermore, the utility of tissue PO2 monitoring to highlight the local oxygen supply-demand balance, and dynamic O2 challenge testing to assess microcirculatory function merit further investigation.

This long-term septic model exhibited an early decline in tissue oxygenation, the degree of which related to predicted mortality. Clinical and biochemical deterioration, however, progressed despite cardiovascular recovery. Early circulatory dysfunction may thus be an important trigger for downstream processes that result in multi-organ failure. Furthermore, the utility of tissue PO2 monitoring to highlight the local oxygen supply-demand balance, and dynamic O2 challenge testing to assess microcirculatory function merit further investigation.

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15 citations in Web of Science®
16 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Institute of Anesthesiology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2011
Deposited On:13 Jan 2012 13:15
Last Modified:05 Apr 2016 15:18
Publisher:Springer
ISSN:0342-4642
Publisher DOI:10.1007/s00134-011-2227-z
PubMed ID:21533572
Permanent URL: http://doi.org/10.5167/uzh-53823

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