Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-54040
Robinson, J A (2011). Protein epitope mimetics as anti-infectives. Current Opinion in Chemical Biology, 15(3):379-386.
|Accepted Version (English)|
PDF (Full manuscript)
View at publisher
There is growing interest in the design of synthetic molecules that mimic the structures and functions of epitopes found on the surface of peptides and proteins. Epitope mimetics can provide valuable tools to probe complex biological processes, as well as interesting leads for drug and vaccine discovery. One application of epitope mimetics is reviewed here, focusing on mimetics of the cationic antimicrobial peptides that form part of the innate immune response to microbial and viral infection in many organisms. Mimetics of these naturally occurring peptides and proteins may be useful to explore mechanisms of antimicrobial and immunomodulatory action, and as a potential source of new antibiotics to address one of the most pressing current threats to human health.
246 downloads since deposited on 09 Jan 2012
96 downloads since 12 months
|Item Type:||Journal Article, refereed, further contribution|
|Communities & Collections:||07 Faculty of Science > Department of Chemistry|
|Dewey Decimal Classification:||540 Chemistry|
|Deposited On:||09 Jan 2012 16:14|
|Last Modified:||05 Jun 2014 16:39|
Users (please log in): suggest update or correction for this item
Repository Staff Only: item control page