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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-54186

Hofer, M; Schmid, C; Benden, C; Speich, R; Inci, I; Weder, W; Boehler, A (2012). Diabetes mellitus and survival in cystic fibrosis patients after lung transplantation. Journal of Cystic Fibrosis, 11(2):131-136.

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BACKGROUND: Diabetes mellitus (DM) is common in CF and associated with more severe disease. It is unclear whether DM influences outcome of lung transplantation (LTx). METHODS: One hundred twenty-three CF patients evaluated for LTx at our centre were included. Survival was calculated. RESULTS: Patients with and without DM did not differ with regard to gender, age, FEV(1) and BMI prior to LTx. Eighty patients (65%) had a diagnosis of DM before and 13 (11%) only after LTx. Recipients with DM had a significantly higher 1- and 5-year survival (89% and 71%) than those without (71% and 51%). In the multivariate Cox-regression analysis, DM had no impact on LTx-survival. CONCLUSIONS: One- and five-year survival rates after LTx tend to be better in CF recipients with DM compared to those without DM. No impact of DM on the development of BOS was found.


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Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic and Policlinic for Internal Medicine
04 Faculty of Medicine > University Hospital Zurich > Clinic for Pneumology
04 Faculty of Medicine > University Hospital Zurich > Clinic for Endocrinology and Diabetology
Dewey Decimal Classification:610 Medicine & health
Deposited On:13 Jan 2012 20:15
Last Modified:01 Dec 2013 20:44
Publisher DOI:10.1016/j.jcf.2011.10.005
PubMed ID:22112935

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