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Prinzipien des perioperativen Gerinnungsmanagements


Ganter, M T; Hofer, C K (2011). Prinzipien des perioperativen Gerinnungsmanagements. Der Chirurg, 82(7):635-644.

Abstract

The coagulation system is a complex network of interacting proteins and cells with extensive sensitivity, amplification and control pathways. The system represents a delicate balance between procoagulant and anticoagulant as well as profibrinolytic and antifibrinolytic activities. Clinically relevant phenotypes, e.g. bleeding and thrombosis, occur immediately when this balance is no longer in equilibrium. A correct understanding of the complex coagulation pathophysiology in the perioperative setting is essential for an effective treatment. In a bleeding patient, patient's history, clinical findings, routine and advanced laboratory coagulation testing as well as point-of-care coagulation monitoring help to reliably and readily identify the underlying coagulation disorder. Modern coagulation management is proactive, individualized, balanced and follows clearly defined algorithms. Coagulopathic bleeding can be successfully controlled with specific interventions in the coagulation system.

The coagulation system is a complex network of interacting proteins and cells with extensive sensitivity, amplification and control pathways. The system represents a delicate balance between procoagulant and anticoagulant as well as profibrinolytic and antifibrinolytic activities. Clinically relevant phenotypes, e.g. bleeding and thrombosis, occur immediately when this balance is no longer in equilibrium. A correct understanding of the complex coagulation pathophysiology in the perioperative setting is essential for an effective treatment. In a bleeding patient, patient's history, clinical findings, routine and advanced laboratory coagulation testing as well as point-of-care coagulation monitoring help to reliably and readily identify the underlying coagulation disorder. Modern coagulation management is proactive, individualized, balanced and follows clearly defined algorithms. Coagulopathic bleeding can be successfully controlled with specific interventions in the coagulation system.

Citations

1 citation in Web of Science®
2 citations in Scopus®
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Additional indexing

Other titles:Principles of perioperative coagulation management
Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Institute of Anesthesiology
Dewey Decimal Classification:610 Medicine & health
Uncontrolled Keywords:review
Language:German
Date:2011
Deposited On:15 Jan 2012 08:35
Last Modified:05 Apr 2016 15:19
Publisher:Springer
ISSN:0009-4722
Additional Information:Ebenfalls publiziert in: Gefässchirurgie, 16(6): 435-444.
Publisher DOI:10.1007/s00104-010-2052-x
Related URLs:http://dx.doi.org/10.1007/s00772-011-0946-7
PubMed ID:21735358

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