Quick Search:

uzh logo
Browse by:
bullet
bullet
bullet
bullet

Zurich Open Repository and Archive 

Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-54198

Sørensen, B; Spahn, D R; Innerhofer, P; Spannagl, M; Rossaint, R (2011). Clinical review: Prothrombin complex concentrates - evaluation of safety and thrombogenicity. Critical Care, 15(1):201-209.

[img]
Preview
Published Version
PDF
231Kb

Abstract

Prothrombin complex concentrates (PCCs) are used mainly for emergency reversal of vitamin K antagonist therapy. Historically, the major drawback with PCCs has been the risk of thrombotic complications. The aims of the present review are to examine thrombotic complications reported with PCCs, and to compare the safety of PCCs with human fresh frozen plasma. The risk of thrombotic complications may be increased by underlying disease, high or frequent PCC dosing, and poorly balanced PCC constituents. The causes of PCC thrombogenicity remain uncertain but accumulating evidence indicates the importance of factor II (prothrombin). With the inclusion of coagulation inhibitors and other manufacturing improvements, today's PCCs may be considered safer than earlier products. PCCs may be considered preferable to fresh frozen plasma for emergency anticoagulant reversal, and this is reflected in the latest British and American guidelines. Care should be taken to avoid excessive substitution with prothrombin, however, and accurate monitoring of patients' coagulation status may allow thrombotic risk to be reduced. The risk of a thrombotic complication due to treatment with PCCs should be weighed against the need for rapid and effective correction of coagulopathy.

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Institute of Anesthesiology
DDC:610 Medicine & health
Language:English
Date:2011
Deposited On:08 Jan 2012 11:08
Last Modified:02 Dec 2013 12:38
Publisher:BioMed Central
ISSN:1364-8535
Additional Information:Erratum in: Crit Care. 2011;15(2):409.
Publisher DOI:10.1186/cc9311
PubMed ID:21345266
Citations:Web of Science®. Times Cited: 43
Google Scholar™

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page