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Spontaneous formation of a vesicle multilayer on top of an exponentially growing polyelectrolyte multilayer mediated by diffusing poly-L-lysine


Graf, N; Thomasson, E; Tanno, A; Vörös, J; Zambelli, T (2011). Spontaneous formation of a vesicle multilayer on top of an exponentially growing polyelectrolyte multilayer mediated by diffusing poly-L-lysine. Journal of Physical Chemistry. B, 115(43):12386-12391.

Abstract

We observed the spontaneous formation of vesicle-multilayers on top of a polyelectrolyte multilayer (PEM). By varying the thickness of underlying PEM (uPEM) it was possible to tailor the amount of adsorbing liposomes. Thereby, the loading capacity could be increased up to 17 times with respect to a monolayer of vesicles for an uPEM of 50.5 bilayers. We, furthermore, proved that the formation of the vesicle multilayer is due to the ability of poly-L-lysine to diffuse within the uPEM. This method could be interesting for applications in sensors and drug delivery systems where the increase in loading capacity is highly desired.

We observed the spontaneous formation of vesicle-multilayers on top of a polyelectrolyte multilayer (PEM). By varying the thickness of underlying PEM (uPEM) it was possible to tailor the amount of adsorbing liposomes. Thereby, the loading capacity could be increased up to 17 times with respect to a monolayer of vesicles for an uPEM of 50.5 bilayers. We, furthermore, proved that the formation of the vesicle multilayer is due to the ability of poly-L-lysine to diffuse within the uPEM. This method could be interesting for applications in sensors and drug delivery systems where the increase in loading capacity is highly desired.

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10 citations in Web of Science®
8 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Biomedical Engineering
Dewey Decimal Classification:170 Ethics
610 Medicine & health
Language:English
Date:2011
Deposited On:12 Jan 2012 17:04
Last Modified:05 Apr 2016 15:19
Publisher:American Chemical Society
ISSN:1520-5207
Publisher DOI:https://doi.org/10.1021/jp206700r

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