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Diabetes mellitus, glycated haemoglobin and C-peptide levels in relation to pancreatic cancer risk: a study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort


Grote, V A; Rohrmann, S; Nieters, A; Dossus, L; Tjønneland, A; Halkjær, J; Overvad, K; Fagherazzi, G; Boutron-Ruault, M C; Morois, S; Teucher, B; Becker, S; Sluik, D; Boeing, H; Trichopoulou, A; Lagiou, P; Trichopoulos, D; Palli, D; Pala, V; Tumino, R; Vineis, P; Panico, S; Rodríguez, L; Duell, E J; Molina-Montes, E; Dorronsoro, M; Huerta, J M; Ardanaz, E; Jeurnink, S M; Beulens, J W J; Peeters, P H M; Sund, M; Ye, W; Lindkvist, B; Johansen, D; Khaw, K T; Wareham, N; Allen, N; Crowe, F; Jenab, M; Romieu, I; Michaud, D S; Riboli, E; Romaguera, D; Bueno-de-Mesquita, H B; Kaaks, R (2011). Diabetes mellitus, glycated haemoglobin and C-peptide levels in relation to pancreatic cancer risk: a study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Diabetologia, 54(12):3037-3046.

Abstract

Our data on HbA(1c) show that individuals who develop exocrine pancreatic cancer tend to have moderate increases in HbA(1c) levels, relatively independently of obesity and insulin resistance-the classic and major risk factors for type 2 diabetes. While there is no strong difference by lag time, more data are needed on this in order to reach a firm conclusion.

Our data on HbA(1c) show that individuals who develop exocrine pancreatic cancer tend to have moderate increases in HbA(1c) levels, relatively independently of obesity and insulin resistance-the classic and major risk factors for type 2 diabetes. While there is no strong difference by lag time, more data are needed on this in order to reach a firm conclusion.

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27 citations in Web of Science®
30 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Epidemiology, Biostatistics and Prevention Institute (EBPI)
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2011
Deposited On:25 Jan 2012 12:41
Last Modified:05 Apr 2016 15:20
Publisher:Springer
ISSN:0012-186X
Additional Information:The original publication is available at www.springerlink.com
Publisher DOI:10.1007/s00125-011-2316-0
PubMed ID:21953276
Permanent URL: http://doi.org/10.5167/uzh-54310

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