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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-54313

Rohrmann, S; Linseisen, J; Becker, S; Allen, N; Schlehofer, B; Overvad, K; Olsen, A; Tjønneland, A; Melin, B S; Lund, E; Vineis, P; Grioni, S; Tumino, R; Palli, D; Mattiello, A; Bonet, C; Chirlaque, M D; Sánchez, M J; Rodríguez, L; Dorronsoro, M; Ardanaz, E; Lagiou, P; Trichopoulou, A; Trichopoulos, D; Dossus, L; Grote, V A; Boeing, H; Aleksandrova, K; Bueno-de-Mesquita, H B; van Duijnhoven, F J B; Peeters, P H M; Khaw, K T; Wareham, N J; Key, T J; Rinaldi, S; Romieux, I; Gallo, V; Michaud, D S; Riboli, E; Kaaks, R (2011). Concentrations of IGF-I and IGFBP-3 and brain tumor risk in the European Prospective Investigation into Cancer and Nutrition. Cancer Epidemiology Biomarkers & Prevention, 20(10):2174-2182.

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Background: Insulin-like growth factor-1 (IGF-I) is important in normal brain development but in the adult brain, IGF-I overexpression may be a risk factor for tumor development.

Methods: We examined the association between circulating concentrations of IGF-I and IGFBP-3 in relation to risk of gliomas (74 low-grade, 206 high-grade gliomas), meningiomas (n = 174) and acoustic neuromas (n = 49) by using a case–control design nested in the European Prospective Investigation into Cancer and Nutrition. IGF-I and IGFBP-3 were measured by ELISAs.Conditional logistic regression was used to compute ORs and corresponding 95% CIs.

Results: The risk of low-grade gliomas was elevated with increased IGF-I (OR = 3.60, 95% CI: 1.11–11.7; top vs. bottom quartile) and decreased with elevated IGFBP-3 concentrations (OR = 0.28, 95% CI: 0.09–0.84) after mutual adjustment of these two factors; these results became nonsignificant after exclusion of the first year of follow-up. No association was observed for high-grade gliomas or meningiomas. Both high IGF-I and IGFBP-3 concentrations were associated with risk of acoustic neuromas (IGF-I: OR = 6.63, 95% CI: 2.27–19.4, top vs. bottom tertile; IGFBP-3: OR = 7.07, 95% CI: 2.32–21.6), even after excluding the first year of follow-up.

Conclusion: High concentrations of IGF-I might be positively associated with risk of low-grade gliomas and acoustic neuromas, although we cannot exclude reverse causation, in particular for low-grade gliomas.


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Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Epidemiology, Biostatistics and Prevention Institute (EBPI)
Dewey Decimal Classification:610 Medicine & health
Deposited On:25 Jan 2012 13:01
Last Modified:05 Apr 2016 15:20
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:10.1158/1055-9965.EPI-11-0179
PubMed ID:21788435

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