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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-54546

Zeilhofer, H U; Wildner, H; Yevenes, G E (2012). Fast synaptic inhibition in spinal sensory processing and pain control. Physiological Reviews, 92(1):193-235.

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Abstract

The two amino acids GABA and glycine mediate fast inhibitory neurotransmission in
different CNS areas and serve pivotal roles in the spinal sensory processing. Under
healthy conditions, they limit the excitability of spinal terminals of primary sensory nerve
fibers and of intrinsic dorsal horn neurons through pre- and postsynaptic mechanisms, and thereby
facilitate the spatial and temporal discrimination of sensory stimuli. Removal of fast inhibition not
only reduces the fidelity of normal sensory processing but also provokes symptoms very much
reminiscent of pathological and chronic pain syndromes. This review summarizes our knowledge of
the molecular bases of spinal inhibitory neurotransmission and its organization in dorsal horn
sensory circuits. Particular emphasis is placed on the role and mechanisms of spinal inhibitory
malfunction in inflammatory and neuropathic chronic pain syndromes.

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > Institute of Pharmacology and Toxicology
DDC:570 Life sciences; biology
610 Medicine & health
Language:English
Date:2012
Deposited On:06 Jan 2012 14:40
Last Modified:08 Feb 2014 03:34
Publisher:American Physiological Society
ISSN:0031-9333
Free access at:Official URL. An embargo period may apply.
Publisher DOI:10.1152/physrev.00043.2010
Official URL:http://physrev.physiology.org/cgi/content/full/92/1/193?ijkey=LTqvOifVk8AnE&keytype=ref&siteid=physiology
PubMed ID:22298656
Citations:Web of Science®. Times Cited: 28
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