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Adenovirus-triggered innate signalling pathways


Fejer, G; Freudenberg, M; Greber, U F; Gyory, I (2011). Adenovirus-triggered innate signalling pathways. European Journal of Microbiology and Immunology, 1(4):279-288.

Abstract

Adenoviruses are important infectious agents and also emerging vectors in different biomedical applications. These viruses elicit a strong innate and adaptive immune response, which influences both the course of disease and the success of the applied vectors. Several Toll-like Receptor (TLR)-dependent and -independent mechanisms contribute to these responses. Understanding of the involved viral and cellular factors is crucial for the treatment of various adenovirus diseases and the optimal design of adenovirus vector applications. Here we summarize our current understanding of the complex nature of adenovirus-induced innate immune mechanisms.

Adenoviruses are important infectious agents and also emerging vectors in different biomedical applications. These viruses elicit a strong innate and adaptive immune response, which influences both the course of disease and the success of the applied vectors. Several Toll-like Receptor (TLR)-dependent and -independent mechanisms contribute to these responses. Understanding of the involved viral and cellular factors is crucial for the treatment of various adenovirus diseases and the optimal design of adenovirus vector applications. Here we summarize our current understanding of the complex nature of adenovirus-induced innate immune mechanisms.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Institute of Molecular Life Sciences
Dewey Decimal Classification:570 Life sciences; biology
Language:English
Date:December 2011
Deposited On:09 Jan 2012 13:14
Last Modified:05 Apr 2016 15:21
Publisher:Akadémiai Kiadó
ISSN:2062-509X
Publisher DOI:10.1556/EuJMI.1.2011.4.3
Permanent URL: http://doi.org/10.5167/uzh-54791

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