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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-54801

Kook, P H; Schellenberg, S; Rentsch, K M; Reusch, C E; Glaus, T M (2011). Effect of twice-daily oral administration of hydrocortisone on the bile acids composition of gallbladder bile in dogs. American Journal of Veterinary Research, 72(12):1607-1612.

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Abstract

Objective-To investigate the effects of twice-daily oral administration of hydrocortisone on the bile acids composition of gallbladder bile in dogs. Animals-6 placebo-treated control dogs and 6 hydrocortisone-treated dogs. Procedures-Dogs received hydrocortisone (median dose, 8.5 mg/kg) or a gelatin capsule (control group) orally every 12 hours for 84 days. Gallbladder bile samples were obtained via percutaneous ultrasound-guided cholecystocentesis from each dog before (day 0 [baseline]), during (days 28, 56, and 84), and after (days 28p, 56p, and 84p) treatment for differentiated quantification of unconjugated bile acids and taurine-conjugated and glycine-conjugated bile acids via high-performance liquid chromatography-tandem mass spectrometry. Results-Treatment with hydrocortisone for 84 days resulted in significant and reversible increases in the concentrations of unconjugated bile acids (ie, cholic, chenodeoxycholic, and deoxycholic acids) and a significant and reversible decrease in the concentration of total taurine-conjugated bile acids, compared with baseline or control group values. Treatment with hydrocortisone had no effect on bile concentrations of glycine-conjugated bile acids. Conclusions and Clinical Relevance-In dogs, hydrocortisone administration caused reversible shifts toward higher concentrations of the more hydrophobic unconjugated bile acids (chenodeoxycholic acid and deoxycholic acid) and toward lower concentrations of the amphipathic taurine-conjugated bile acids in gallbladder bile. These data suggest that similar bile acids changes could cause major alterations in gallbladder structure or function over time in hypercortisolemic dogs.

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Institute of Clinical Chemistry
05 Vetsuisse Faculty > Veterinary Clinic > Department of Small Animals > Clinic for Small Animal Internal Medicine
DDC:570 Life sciences; biology
610 Medicine & health
630 Agriculture
540 Chemistry
Language:English
Date:2011
Deposited On:01 Feb 2012 11:30
Last Modified:07 Jan 2013 10:15
Publisher:American Veterinary Medical Association
ISSN:0002-9645
Publisher DOI:10.2460/ajvr.72.12.1607
PubMed ID:22126688
Citations:Google Scholar™
Scopus®. Citation Count: 1

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