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Keiser, O; Spycher, B; Rauch, A; Calmy, A; Cavassini, M; Glass, T R; Nicca, D; Ledergerber, B; Egger, M (2012). Outcomes of antiretroviral therapy in the Swiss HIV Cohort Study: Latent class analysis. AIDS and Behavior, 16(2):245-255.

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An in-depth understanding of the different groups that make up the HIV-infected population should inform prevention and care. Using latent class analysis (LCA) we identified seven groups with similar socio-demographic and behavioral characteristics at enrolment in the Swiss HIV Cohort Study: older gay men, younger gay men, older heterosexual men, injection drug users, single migrants, migrant women in partnerships and heterosexual men and women. Outcomes of combination antiretroviral therapy (ART) were analyzed in 1,633 patients starting ART. Compared to older gay men, the probability of a virologic response to ART was reduced in single migrants, in older heterosexual men and in IDUs. Loss to follow-up was higher in single migrants and IDUs, and mortality was increased in older heterosexual men and IDUs. Socio-behavioral groups identified by LCA allow insights above what can be gleaned from traditional transmission groups, and may identify patients who could benefit from targeted interventions.


8 citations in Web of Science®
8 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Infectious Diseases
Dewey Decimal Classification:610 Medicine & health
Deposited On:15 Jan 2012 11:25
Last Modified:05 Apr 2016 15:21
Publisher DOI:10.1007/s10461-011-9971-5
PubMed ID:21630013

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