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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-54806

Ghosh, A; Peduzzi, S; Snyder, M; Schneider, R; Starkey, M; Schwab, M E (2012). Heterogeneous spine loss in layer 5 cortical neurons after spinal cord injury. Cerebral Cortex, 22(6):1309-1317.

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Abstract

A large thoracic spinal cord injury disconnects the hindlimb (HL) sensory-motor cortex from its target, the lumbar spinal cord. The fate of the synaptic structures of the axotomized cortical neurons is not well studied. We evaluated the density of spines on axotomized corticospinal neurons at 3, 7, and 21 days after the injury in adult mice expressing yellow fluorescence protein in a subset of layer 5 neurons. Spine density of the dendritic segment proximal to the soma (in layer 5) declined as early as 3 days after injury, far preceding the onset of somatic atrophy. In the distal segment (in layer 2/3), spine loss was slower and less severe than in the proximal segment. Axotomy of corticospinal axons in the brainstem (pyramidotomy) induced a comparable reduction of spine density, demonstrating that the loss is not restricted to the neurons axotomized in the thoracic spinal cord. Surprisingly, in both forms of injury, the spine density of putative non-axotomized layer 5 neurons was reduced as well. The spine loss may reflect fast rearrangements of cortical circuits after axotomy, for example, by a disconnection of HL cortical neurons from synaptic inputs that no longer provide useful information.

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Balgrist University Hospital, Swiss Spinal Cord Injury Center
07 Faculty of Science > Institute of Neuroinformatics
04 Faculty of Medicine > Brain Research Institute
DDC:570 Life sciences; biology
610 Medicine & health
Language:English
Date:2012
Deposited On:11 Jan 2012 13:52
Last Modified:05 Feb 2014 10:11
Publisher:Oxford University Press
ISSN:1047-3211
Funders:Swiss National Science Foundation (Grants 31-63633.00 and 31-122527), National Center of Competence in Research ‘‘Neural Plasticity and Repair’’ of the Swiss National Science Foundation, Spinal Cord Consortium of the Christopher Reeve Paralysis Foundation (Springfield, NJ), NeuroNe, Network of Excellence of the European Consortium for Research in Neurodegenerative Diseases (Sixth Framework European Union Program), Investigator A.G. is supported by a Society in Science Branco Weiss Fellowship
Publisher DOI:10.1093/cercor/bhr191
PubMed ID:21840844
Citations:Web of Science®. Times Cited: 4
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Scopus®. Citation Count: 6

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