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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-55

Pap, T; Gay, R E; Müller-Ladner, U; Gay, S (2002). Ex vivo gene transfer in the years to come. Arthritis Research, 4:10.

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Abstract

Synovial fibroblasts (SFs) have become a major target for ex vivo gene transfer in rheumatoid arthritis (RA), but efficient transduction of RA-SFs still is a major problem. The low proliferation rate and heterogeneity of RA-SFs, together with their lack of highly specific surface receptors, have hampered a more extensive application of this technique. Improving transduction protocols with conventional viral vectors, therefore, as well as developing novel strategies, such as alternative target cells, and novel delivery systems constitute a major challenge. Recent progress in this field will lead to the achievement of high transgene expression, and will facilitate the use of gene transfer in human trials.

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10 citations in Web of Science®
13 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Rheumatology Clinic and Institute of Physical Medicine
DDC:610 Medicine & health
Language:English
Date:2002
Deposited On:11 Feb 2008 12:12
Last Modified:27 Nov 2013 20:04
Publisher:BioMed Central
ISSN:1465-9905
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:10.1186/ar377
Official URL:http://arthritis-research.com/content/pdf/ar377.pdf
PubMed ID:11879532

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