Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-55
Pap, T; Gay, R E; Müller-Ladner, U; Gay, S (2002). Ex vivo gene transfer in the years to come. Arthritis Research, 4:10.
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Synovial fibroblasts (SFs) have become a major target for ex vivo gene transfer in rheumatoid arthritis (RA), but efficient transduction of RA-SFs still is a major problem. The low proliferation rate and heterogeneity of RA-SFs, together with their lack of highly specific surface receptors, have hampered a more extensive application of this technique. Improving transduction protocols with conventional viral vectors, therefore, as well as developing novel strategies, such as alternative target cells, and novel delivery systems constitute a major challenge. Recent progress in this field will lead to the achievement of high transgene expression, and will facilitate the use of gene transfer in human trials.
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|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||04 Faculty of Medicine > University Hospital Zurich > Rheumatology Clinic and Institute of Physical Medicine|
|Dewey Decimal Classification:||610 Medicine & health|
|Deposited On:||11 Feb 2008 12:12|
|Last Modified:||05 Apr 2016 12:12|
|Free access at:||Publisher DOI. An embargo period may apply.|
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