UZH-Logo

Maintenance Infos

Ex vivo gene transfer in the years to come


Pap, T; Gay, R E; Müller-Ladner, U; Gay, S (2002). Ex vivo gene transfer in the years to come. Arthritis Research, 4:10.

Abstract

Synovial fibroblasts (SFs) have become a major target for ex vivo gene transfer in rheumatoid arthritis (RA), but efficient transduction of RA-SFs still is a major problem. The low proliferation rate and heterogeneity of RA-SFs, together with their lack of highly specific surface receptors, have hampered a more extensive application of this technique. Improving transduction protocols with conventional viral vectors, therefore, as well as developing novel strategies, such as alternative target cells, and novel delivery systems constitute a major challenge. Recent progress in this field will lead to the achievement of high transgene expression, and will facilitate the use of gene transfer in human trials.

Abstract

Synovial fibroblasts (SFs) have become a major target for ex vivo gene transfer in rheumatoid arthritis (RA), but efficient transduction of RA-SFs still is a major problem. The low proliferation rate and heterogeneity of RA-SFs, together with their lack of highly specific surface receptors, have hampered a more extensive application of this technique. Improving transduction protocols with conventional viral vectors, therefore, as well as developing novel strategies, such as alternative target cells, and novel delivery systems constitute a major challenge. Recent progress in this field will lead to the achievement of high transgene expression, and will facilitate the use of gene transfer in human trials.

Citations

10 citations in Web of Science®
13 citations in Scopus®
Google Scholar™

Altmetrics

Downloads

0 downloads since deposited on 11 Feb 2008
11 downloads since 12 months

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Rheumatology Clinic and Institute of Physical Medicine
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2002
Deposited On:11 Feb 2008 12:12
Last Modified:05 Apr 2016 12:12
Publisher:BioMed Central
ISSN:1465-9905
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1186/ar377
Official URL:http://arthritis-research.com/content/pdf/ar377.pdf
PubMed ID:11879532

Download

[img]
Preview
Content: Published Version
Filetype: PDF
Size: 110kB
View at publisher

TrendTerms

TrendTerms displays relevant terms of the abstract of this publication and related documents on a map. The terms and their relations were extracted from ZORA using word statistics. Their timelines are taken from ZORA as well. The bubble size of a term is proportional to the number of documents where the term occurs. Red, orange, yellow and green colors are used for terms that occur in the current document; red indicates high interlinkedness of a term with other terms, orange, yellow and green decreasing interlinkedness. Blue is used for terms that have a relation with the terms in this document, but occur in other documents.
You can navigate and zoom the map. Mouse-hovering a term displays its timeline, clicking it yields the associated documents.

Author Collaborations