Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-55078
Calcinaghi, N; Jolivet, R; Wyss, M T; Ametamey, S M; Gasparini, F; Buck, A; Weber, B (2011). Metabotropic glutamate receptor mGluR5 is not involved in the early hemodynamic response. Journal of Cerebral Blood Flow and Metabolism, 31(9):e1-e10.
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Activation of astrocytic metabotropic glutamate receptor 5 (mGluR5) is postulated to elicit calcium transients, triggering a chain of events that ultimately regulates cerebral blood flow by changing the tone of smooth muscle cells of nearby arterioles. Using concurrent in vivo optical imaging and determination of receptor occupancy with (11)C-ABP688, we report here that blocking ∼80% of mGluR5 in vivo does not affect transient hemodynamic responses on brief whisker stimulations while transiently reducing neuronal activity as measured by voltage-sensitive dye imaging. Our results show that mechanisms other than activation of mGluR5 are required to trigger the initial hemodynamic response in normal physiological conditions.
|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||04 Faculty of Medicine > Institute of Pharmacology and Toxicology|
04 Faculty of Medicine > University Hospital Zurich > Clinic for Nuclear Medicine
|DDC:||570 Life sciences; biology|
610 Medicine & health
|Deposited On:||16 Jan 2012 10:09|
|Last Modified:||03 Dec 2013 19:46|
|Publisher:||Nature Publishing Group|
|Citations:||Web of Science®. Times cited: 10|
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