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Metabotropic glutamate receptor mGluR5 is not involved in the early hemodynamic response


Calcinaghi, N; Jolivet, R; Wyss, M T; Ametamey, S M; Gasparini, F; Buck, A; Weber, B (2011). Metabotropic glutamate receptor mGluR5 is not involved in the early hemodynamic response. Journal of Cerebral Blood Flow and Metabolism, 31(9):e1-e10.

Abstract

Activation of astrocytic metabotropic glutamate receptor 5 (mGluR5) is postulated to elicit calcium transients, triggering a chain of events that ultimately regulates cerebral blood flow by changing the tone of smooth muscle cells of nearby arterioles. Using concurrent in vivo optical imaging and determination of receptor occupancy with (11)C-ABP688, we report here that blocking ∼80% of mGluR5 in vivo does not affect transient hemodynamic responses on brief whisker stimulations while transiently reducing neuronal activity as measured by voltage-sensitive dye imaging. Our results show that mechanisms other than activation of mGluR5 are required to trigger the initial hemodynamic response in normal physiological conditions.

Activation of astrocytic metabotropic glutamate receptor 5 (mGluR5) is postulated to elicit calcium transients, triggering a chain of events that ultimately regulates cerebral blood flow by changing the tone of smooth muscle cells of nearby arterioles. Using concurrent in vivo optical imaging and determination of receptor occupancy with (11)C-ABP688, we report here that blocking ∼80% of mGluR5 in vivo does not affect transient hemodynamic responses on brief whisker stimulations while transiently reducing neuronal activity as measured by voltage-sensitive dye imaging. Our results show that mechanisms other than activation of mGluR5 are required to trigger the initial hemodynamic response in normal physiological conditions.

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23 citations in Web of Science®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Pharmacology and Toxicology
04 Faculty of Medicine > University Hospital Zurich > Clinic for Nuclear Medicine
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:September 2011
Deposited On:16 Jan 2012 09:09
Last Modified:05 Apr 2016 15:22
Publisher:Nature Publishing Group
ISSN:0271-678X
Publisher DOI:10.1038/jcbfm.2011.96
PubMed ID:21731033
Permanent URL: http://doi.org/10.5167/uzh-55078

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