Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-5515
Ahmadi, S; Lippross, S; Neuhuber, W L; Zeilhofer, H U (2002). PGE(2)selectively blocks inhibitory glycinergic neurotransmission onto rat superficial dorsal horn neurons. Nature Neuroscience, 5(1):34-40.
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Despite the crucial role that prostaglandins (PGs)have in the sensitization of the central nervous system to pain, their cellular and molecular targets leading to increased pain perception have remained elusive. Here we investigated the effects of PGE(2) on fast synaptic transmission onto neurons in the rat spinal cord dorsal horn, the first site of synaptic integration in the pain pathway. We identified the inhibitory (strychnine-sensitive) glycine receptor as a specific target of PGE(2). PGE(2), but not PGF(2 alpha), PGD(2) or PGI(2), reduced inhibitory glycinergic synaptic transmission in low nanomolar concentrations, whereas GABAA, AMPA and NMDA receptor-mediated transmission remained unaffected. Inhibition of glycine receptors occurred via a postsynaptic mechanism involving the activation of EP2 receptors, cholera-toxin-sensitive G-proteins and cAMP-dependent protein kinase. Via this mechanism, PGE(2) may facilitate the transmission of nociceptive input through the spinal cord dorsal horn to higher brain areas where pain becomes conscious.
|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||04 Faculty of Medicine > Institute of Pharmacology and Toxicology|
|DDC:||570 Life sciences; biology|
610 Medicine & health
|Deposited On:||26 Mar 2009 13:42|
|Last Modified:||01 Dec 2013 08:14|
|Publisher:||Nature Publishing Group|
|Citations:||Web of Science®. Times Cited: 164|
Scopus®. Citation Count: 178
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