Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-5521
Zeilhofer, H U; Schorr, W (2000). Role of interleukin-8 in neutrophil signaling. Current Opinion in Hematology, 7(3):178-182.
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Interleukin-8 was originally discovered as one of the first chemokines activating neutrophil granulocytes (neutrophils) after secretion by lipopolysaccharide-stimulated monocytes. A wealth of information has been gathered concerning the intracellular events mediated by interleukin-8 and the role of interleukin-8 in numerous physiologic and pathophysiologic processes. We discuss recent advances in the understanding of the initial intracellular signals elicited by interleukin-8. Detailed investigation of these events has led to the identification of subtle but significant differences in the signal transduction processes evoked by interleukin-8 receptors. In particular, much has been learned concerning differences in the cellular mechanisms leading to desensitization, internalization, and recycling of interleukin-8 receptors, and functional consequences of interleukin-8 receptor diversity are now being unraveled.
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|Item Type:||Journal Article, refereed, further contribution|
|Communities & Collections:||04 Faculty of Medicine > Institute of Pharmacology and Toxicology|
|DDC:||570 Life sciences; biology
610 Medicine & health
|Deposited On:||27 Mar 2009 07:07|
|Last Modified:||27 Nov 2013 20:00|
|Publisher:||Lippincott Wiliams & Wilkins|
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