UZH-Logo

Deep brain stimulation in parkinsonian patients — ethical evaluation of cognitive, affective, and behavioral sequelae


Müller, S; Christen, M (2011). Deep brain stimulation in parkinsonian patients — ethical evaluation of cognitive, affective, and behavioral sequelae. AJOB Neuroscience, 2(1):3-13.

Abstract

Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an important therapeutic advancement for the treatment of Parkinson's disease (PD). Its beneficial effects on motor functions are well established, but its cognitive, affective, and behavioral sequelae come increasingly into the focus of the medical and ethical discussion. In order to evaluate whether these side effects may counteract the beneficial effects of STN DBS on the patient's quality of life, we classify them along the dimensions “measurement complexity” and “weighted life-impact.” Based on this analysis, we discuss their ethical impact and propose guidelines for the clinical setting of STN DBS.

Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an important therapeutic advancement for the treatment of Parkinson's disease (PD). Its beneficial effects on motor functions are well established, but its cognitive, affective, and behavioral sequelae come increasingly into the focus of the medical and ethical discussion. In order to evaluate whether these side effects may counteract the beneficial effects of STN DBS on the patient's quality of life, we classify them along the dimensions “measurement complexity” and “weighted life-impact.” Based on this analysis, we discuss their ethical impact and propose guidelines for the clinical setting of STN DBS.

Citations

Altmetrics

Downloads

482 downloads since deposited on 13 Jan 2012
151 downloads since 12 months
Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Biomedical Ethics and History of Medicine
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2011
Deposited On:13 Jan 2012 08:39
Last Modified:05 Apr 2016 15:23
Publisher:Taylor & Francis
ISSN:2150-7759
Publisher DOI:10.1080/21507740.2010.533151
Official URL:http://www.tandfonline.com/doi/abs/10.1080/21507740.2010.533151
Permanent URL: http://doi.org/10.5167/uzh-55241

Download

[img]Content: Published Version
Filetype: PDF - Registered users only
Size: 214kB
View at publisher

[img]
Preview
Content: Accepted Version
Filetype: PDF
Size: 585kB

TrendTerms

TrendTerms displays relevant terms of the abstract of this publication and related documents on a map. The terms and their relations were extracted from ZORA using word statistics. Their timelines are taken from ZORA as well. The bubble size of a term is proportional to the number of documents where the term occurs. Red, orange, yellow and green colors are used for terms that occur in the current document; red indicates high interlinkedness of a term with other terms, orange, yellow and green decreasing interlinkedness. Blue is used for terms that have a relation with the terms in this document, but occur in other documents.
You can navigate and zoom the map. Mouse-hovering a term displays its timeline, clicking it yields the associated documents.

Author Collaborations