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Zinkernagel, A S; Hruz, P; Uchiyama, S; von Köckritz-Blickwede, M; Schuepbach, R A; Hayashi, T; Carson, D A; Nizet, V (2012). Importance of toll-like receptor 9 in host defense against M1T1 Group A Streptococcus infections. Journal of Innate Immunity, 4(2):213-218.

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Abstract

Timely recognition and elimination of invasive group A Streptococcus (GAS) by innate immunity is crucial to control infection. The intracellular pattern recognition receptor Toll-like receptor 9 (TLR9) promotes macrophage hypoxia-inducible factor-1α levels, oxidative burst and nitric oxide production in response to GAS. TLR9 contributes to GAS clearance in vivo in both localized cutaneous and systemic infection models.

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Division of Surgical Research
04 Faculty of Medicine > University Hospital Zurich > Division of Surgical Intensive Care Medicine
04 Faculty of Medicine > University Hospital Zurich > Clinic for Infectious Diseases
DDC:610 Medicine & health
Language:English
Date:2012
Deposited On:21 Jan 2012 10:37
Last Modified:27 Nov 2013 22:20
Publisher:Karger
ISSN:1662-811X
Publisher DOI:10.1159/000329550
PubMed ID:21860217
Citations:Web of Science®. Times Cited: 3
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Scopus®. Citation Count: 5

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