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Modified plastic compression of collagen hydrogels provides an ideal matrix for clinically applicable skin substitutes


Braziulis, E; Diezi, M; Biedermann, T; Pontiggia, L; Schmucki, M; Hartmann-Fritsch, F; Luginbühl, J; Schiestl, C; Meuli, M; Reichmann, E (2012). Modified plastic compression of collagen hydrogels provides an ideal matrix for clinically applicable skin substitutes. Tissue engineering. Part C, 18(6):464-474.

Abstract

Tissue engineering of clinically applicable dermo-epidermal skin substitutes is crucially dependent on the three-dimensional extracellular matrix, supporting the biological function of epidermal and dermal cells. This matrix essentially determines the mechanical stability of these substitutes to allow for safe and convenient surgical handling. Collagen type I hydrogels yield excellent biological functionality but their mechanical weakness and their tendency to contract and degrade does not allow producing clinically applicable transplants of larger sizes. We show here that plastically compressed collagen type I hydrogels can be produced in clinically relevant sizes (7 x 7 cm), and can be safely and conveniently handled by the surgeon. Most importantly, these dermo-epidermal skin substitutes mature into a near normal skin that can successfully reconstitute full thickness skin defects in an animal model.

Tissue engineering of clinically applicable dermo-epidermal skin substitutes is crucially dependent on the three-dimensional extracellular matrix, supporting the biological function of epidermal and dermal cells. This matrix essentially determines the mechanical stability of these substitutes to allow for safe and convenient surgical handling. Collagen type I hydrogels yield excellent biological functionality but their mechanical weakness and their tendency to contract and degrade does not allow producing clinically applicable transplants of larger sizes. We show here that plastically compressed collagen type I hydrogels can be produced in clinically relevant sizes (7 x 7 cm), and can be safely and conveniently handled by the surgeon. Most importantly, these dermo-epidermal skin substitutes mature into a near normal skin that can successfully reconstitute full thickness skin defects in an animal model.

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24 citations in Web of Science®
25 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Children's Hospital Zurich > Clinic for Surgery
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2012
Deposited On:28 Jan 2012 15:09
Last Modified:05 Apr 2016 15:27
Publisher:Mary Ann Liebert
ISSN:1937-3384
Publisher DOI:10.1089/ten.TEC.2011.0561
PubMed ID:22195768
Permanent URL: http://doi.org/10.5167/uzh-56351

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