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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-56451

Grimm, S; Ernst, J; Boesiger, P; Schuepbach, D; Boeker, H; Northoff, G (2011). Reduced negative BOLD responses in the default-mode network and increased self-focus in depression. World Journal of Biological Psychiatry, 12(8):627-637.

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Abstract

OBJECTIVES:

Functional imaging studies in major depressive disorder (MDD) indicate abnormal resting state neural activity and negative blood oxygenation level-dependent (BOLD) responses (NBRs) in regions of the default-mode network (DMN).
METHODS:

Since activity in DMN regions has been associated with self-relatedness, we investigated neural activity in these regions during self-related emotional judgement and passive picture viewing in 25 patients with MDD and 25 healthy controls in an event-related fMRI design.
RESULTS:

Behaviourally, MDD subjects showed significantly higher ratings of self-relatedness that also correlated with depression symptoms such as hopelessness. Neuroimaging results in MDD patients showed significantly lower negative BOLD responses (NBRs) in anterior medial cortical regions during judgement of self-relatedness while posterior medial regions showed increased NBRs. Unlike in healthy subjects, the anterior medial cortical NBRs were no longer parametrically modulated by the degree of self-relatedness in MDD patients.
CONCLUSIONS:

Our findings suggest that reduced NBRs in the anterior regions of the default-mode network may signify decoupling from self-relatedness in MDD patients with the consecutive abnormal increase of self-focus.

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Biomedical Engineering
DDC:170 Ethics
610 Medicine & health
Language:English
Date:2011
Deposited On:25 Jan 2012 21:58
Last Modified:30 Nov 2013 17:10
Publisher:Informa Healthcare
ISSN:1562-2975
Publisher DOI:10.3109/15622975.2010.545145
PubMed ID:21247256
Citations:Web of Science®. Times Cited: 16
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