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A genome-wide survey and functional brain imaging study identify CTNNBL1 as a memory-related gene


Papassotiropoulos, A; Stefanova, E; Vogler, C; Gschwind, L; Ackermann, S; Spalek, K; Rasch, Björn; Heck, A; Aerni, A; Hanser, E; Demougin, P; Huynh, K D; Luechinger, R; Klarhöfer, M; Novakovic, I; Kostic, V; Boesiger, P; Scheffler, K; de Quervain, D J F (2013). A genome-wide survey and functional brain imaging study identify CTNNBL1 as a memory-related gene. Molecular Psychiatry, 18(2):255-263.

Abstract

Unbiased genome-wide screens combined with imaging data on brain function may identify novel molecular pathways related to human cognition. Here we performed a dense genome-wide screen to identify episodic memory-related gene variants. A genomic locus encoding the brain-expressed beta-catenin-like protein 1 (CTNNBL1) was significantly (P=7 × 10(-8)) associated with verbal memory performance in a cognitively healthy cohort from Switzerland (n=1073) and was replicated in a second cohort from Serbia (n=524; P=0.003). Gene expression studies showed CTNNBL1 genotype-dependent differences in beta-catenin-like protein 1 mRNA levels in the human cortex. Functional magnetic resonance imaging in 322 subjects detected CTNNBL1 genotype-dependent differences in memory-related brain activations. Converging evidence from independent experiments and different methodological approaches suggests a role for CTNNBL1 in human memory.Molecular Psychiatry advance online publication, 22 November 2011; doi:10.1038/mp.2011.148.

Unbiased genome-wide screens combined with imaging data on brain function may identify novel molecular pathways related to human cognition. Here we performed a dense genome-wide screen to identify episodic memory-related gene variants. A genomic locus encoding the brain-expressed beta-catenin-like protein 1 (CTNNBL1) was significantly (P=7 × 10(-8)) associated with verbal memory performance in a cognitively healthy cohort from Switzerland (n=1073) and was replicated in a second cohort from Serbia (n=524; P=0.003). Gene expression studies showed CTNNBL1 genotype-dependent differences in beta-catenin-like protein 1 mRNA levels in the human cortex. Functional magnetic resonance imaging in 322 subjects detected CTNNBL1 genotype-dependent differences in memory-related brain activations. Converging evidence from independent experiments and different methodological approaches suggests a role for CTNNBL1 in human memory.Molecular Psychiatry advance online publication, 22 November 2011; doi:10.1038/mp.2011.148.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:06 Faculty of Arts > Institute of Psychology
04 Faculty of Medicine > Institute of Biomedical Engineering
Dewey Decimal Classification:150 Psychology
170 Ethics
610 Medicine & health
Language:English
Date:2013
Deposited On:28 Jan 2012 16:12
Last Modified:05 Apr 2016 15:27
Publisher:Nature Publishing Group
ISSN:1359-4184
Free access at:PubMed ID. An embargo period may apply.
Publisher DOI:https://doi.org/10.1038/mp.2011.148
PubMed ID:22105620
Permanent URL: https://doi.org/10.5167/uzh-56464

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