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Magnetization exchange with water and T1 relaxation of the downfield resonances in human brain spectra at 3.0 T


MacMillan, E L; Chong, D G Q; Dreher, W; Henning, A; Boesch, C; Kreis, R (2011). Magnetization exchange with water and T1 relaxation of the downfield resonances in human brain spectra at 3.0 T. Magnetic Resonance in Medicine, 65(5):1239-1246.

Abstract

The use of water suppression for in vivo proton MR spectroscopy diminishes the signal intensities from resonances that undergo magnetization exchange with water, particularly those downfield of water. To investigate these exchangeable resonances, an inversion transfer experiment was performed using the metabolite cycling technique for non-water-suppressed MR spectroscopy from a large brain voxel in 11 healthy volunteers at 3.0 T. The exchange rates of the most prominent peaks downfield of water were found to range from 0.5 to 8.9 s(-1), while the T(1) relaxation times in absence of exchange were found to range from 175 to 525 ms. These findings may help toward the assignments of the downfield resonances and a better understanding of the sources of contrast in chemical exchange saturation transfer imaging.

The use of water suppression for in vivo proton MR spectroscopy diminishes the signal intensities from resonances that undergo magnetization exchange with water, particularly those downfield of water. To investigate these exchangeable resonances, an inversion transfer experiment was performed using the metabolite cycling technique for non-water-suppressed MR spectroscopy from a large brain voxel in 11 healthy volunteers at 3.0 T. The exchange rates of the most prominent peaks downfield of water were found to range from 0.5 to 8.9 s(-1), while the T(1) relaxation times in absence of exchange were found to range from 175 to 525 ms. These findings may help toward the assignments of the downfield resonances and a better understanding of the sources of contrast in chemical exchange saturation transfer imaging.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Biomedical Engineering
Dewey Decimal Classification:170 Ethics
610 Medicine & health
Language:English
Date:2011
Deposited On:22 Jan 2012 20:26
Last Modified:05 Apr 2016 15:27
Publisher:Wiley-Blackwell
ISSN:0740-3194
Publisher DOI:10.1002/mrm.22813
PubMed ID:21394768
Permanent URL: http://doi.org/10.5167/uzh-56471

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