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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-56481

Fiechter, M; Ghadri, J R; Wolfrum, M; Kuest, S M; Pazhenkottil, A P; Nkoulou, R N; Herzog, B A; Gebhard, C; Fuchs, T A; Gaemperli, O; Kaufmann, P A (2012). Downstream resource utilization following hybrid cardiac imaging with an integrated cadmium-zinc-telluride/64-slice CT device. European Journal of Nuclear Medicine and Molecular Imaging, 39(3):430-436.

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Low yield of invasive coronary angiography and unnecessary coronary interventions have been identified as key cost drivers in cardiology for evaluation of coronary artery disease (CAD). This has fuelled the search for noninvasive techniques providing comprehensive functional and anatomical information on coronary lesions. We have evaluated the impact of implementation of a novel hybrid cadmium-zinc-telluride (CZT)/64-slice CT camera into the daily clinical routine on downstream resource utilization.

Sixty-two patients with known or suspected CAD were referred for same-day single-session hybrid evaluation with CZT myocardial perfusion imaging (MPI) and coronary CT angiography (CCTA). Hybrid MPI/CCTA images from the integrated CZT/CT camera served for decision-making towards conservative versus invasive management. Based on the hybrid images patients were classified into those with and those without matched findings. Matched findings were defined as the combination of MPI defect with a stenosis by CCTA in the coronary artery subtending the respective territory. All patients with normal MPI and CCTA as well as those with isolated MPI or CCTA finding or combined but unmatched findings were categorized as "no match".

All 23 patients with a matched finding underwent invasive coronary angiography and 21 (91%) were revascularized. Of the 39 patients with no match, 5 (13%, p < 0.001 vs matched) underwent catheterization and 3 (8%, p < 0.001 vs matched) were revascularized.

Cardiac hybrid imaging in CAD evaluation has a profound impact on patient management and may contribute to optimal downstream resource utilization.


6 citations in Web of Science®
12 citations in Scopus®
Google Scholar™



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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Nuclear Medicine
Dewey Decimal Classification:610 Medicine & health
Deposited On:02 Feb 2012 20:32
Last Modified:05 Apr 2016 15:27
ISSN:1619-7070 (P) 1619-7089 (E)
Additional Information:The original publication is available at www.springerlink.com
Publisher DOI:10.1007/s00259-011-1999-2
PubMed ID:22143224

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