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McDonald, Samuel A; Marone, Federica; Hintermüller, Christoph; Mikuljan, Gordan; David, Christian; Stampanoni, Marco (2010). Phase Contrast X-Ray Tomographic Microscopy for Biological and Materials Science Applications. Advanced Engineering Materials, 13(3):116-121.

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Abstract

The application of two approaches for high-throughput, high-resolution X-ray phase contrast tomographic imaging being used at the tomographic microscopy and coherent radiology experiments (TOMCAT) beamline of the SLS is discussed and illustrated. Differential phase contrast (DPC) imaging, using a grating interferometer and a phase-stepping technique, is integrated into the beamline environment at TOMCAT in terms of the fast acquisition and reconstruction of data and the availability to scan samples within an aqueous environment. A second phase contrast method is a modified transfer of intensity approach that can yield the 3D distribution of the decrement of the refractive index of a weakly absorbing object from a single tomographic dataset. The two methods are complementary to one another: the DPC method is characterised by a higher sensitivity and by moderate resolution with larger samples; the modified transfer of intensity approach is particularly suited for small specimens when high resolution (around 1 µm) is required. Both are being applied to investigations in the biological and materials science fields.

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Biomedical Engineering
DDC:170 Ethics
610 Medicine & health
Language:English
Date:2010
Deposited On:04 Jun 2012 12:05
Last Modified:27 Nov 2013 17:45
Publisher:Wiley-VCH
ISSN:1527-2648
Publisher DOI:10.1002/adem.201000219
Citations:Web of Science®. Times Cited: 2
Google Scholar™
Scopus®. Citation Count: 3

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