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Bahde, R; Hölzen, J P; Wolters, H H; Schmidt, H H J; Bock, C T; Lügering, A; Spieker, T; Senninger, N; Brockmann, J G (2011). Course of a HBsAg positive liver transplantation in a hepatitis B and D virus coinfected recipient. Annals of Hepatology, 10(3):355-360.

Full text not available from this repository.

Abstract

The increasing demand for transplantation has led to consideration of liver grafts from donors exposed to hepatitis B virus (HBV). Six transplantations of liver grafts from hepatitis B surface antigen (HBsAg) positive donors have been reported; two recipients suffered from HBV/HDV (hepatitis Delta virus) coinfection and were followed up for 10-12 months. Here, we report a 56 months follow-up of a HBV/HDV-coinfected recipient of a HBsAg positive liver graft. Posttransplant combination prophylaxis consisted of hepatitis immunoglobulin, lamivudine and adefovir dipivoxil. HBsAg remained positive during stable posttransplant follow-up and subclinical HDV reinfection with low replication rate was detected at 1 month. Pegylated interferon therapy was introduced after documentation of histological evidence of mild chronic hepatitis, but without virological response after 48 weeks. Finally, antiviral treatment was switched to tenofovir disoproxil fumarate. More than 50 months posttransplant the recipient revealed clinical symptoms of decompensated liver cirrhosis and has been relisted for liver transplantation. In conclusion HBsAg positive liver grafts in HBsAg positive recipients with HDV coinfection may result in virological recurrence and rapid development of liver cirrhosis.

Citations

4 citations in Web of Science®
3 citations in Scopus®
Google Scholar™

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Visceral and Transplantation Surgery
DDC:610 Medicine & health
Language:English
Date:2011
Deposited On:02 Mar 2012 21:14
Last Modified:27 Nov 2013 18:29
Publisher:Mexican Association of Hepatology
ISSN:1665-2681
Free access at:Official URL. An embargo period may apply.
Official URL:http://www.annalsofhepatology.com/PDF/vol10n3/HP113-16-Course.pdf
Related URLs:http://www.annalsofhepatology.com/ (Publisher)
PubMed ID:21677340

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