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Lebertransplantation


Frei, P; Geier, A; Dutkowski, P; Müllhaupt, B (2011). Lebertransplantation. Therapeutische Umschau, 68(4):219-224.

Abstract

Liver transplantation is the only curative therapy for many liver diseases, mostly chronic liver diseases, occasionally also in acute or fulminant liver failure. Currently, about 100 liver transplantatations are performed each year in Switzerland. Clichy criteria are used for acute liver failure. Liver transplantation for liver cirrhosis improves survival if the Meld-Score is above 15. 5- and 10-year-survival after liver transplantation are 71% and 61%, respectively. With increasing survival after liver transplantation, the management of drug side effects in the late postoperative course becomes important.

Zusammenfassung:

Für viele chronische Lebererkrankungen und auch beim akuten Leberversagen ist eine Lebertransplantation die einzige kurative Therapie. In der Schweiz werden jährlich etwa 100 Lebertransplantationen durchgeführt. Beim akuten Leberversagen gelten die Clichy-Kriterien für die Transplantationsindikation. Bei einer Leberzirrhose hat die Transplantation ab einem MELD-Score von 15 einen günstigen Effekt auf das Langzeitüberleben. Das 5- und 10-Jahresüberleben nach Lebertransplantation beträgt 71% respektive 61%. Bei zunehmendem Langzeitüberleben wird das Management der Medikamentennebenwirkungen und kardiovaskulären Risiken immer wichtiger.

Liver transplantation is the only curative therapy for many liver diseases, mostly chronic liver diseases, occasionally also in acute or fulminant liver failure. Currently, about 100 liver transplantatations are performed each year in Switzerland. Clichy criteria are used for acute liver failure. Liver transplantation for liver cirrhosis improves survival if the Meld-Score is above 15. 5- and 10-year-survival after liver transplantation are 71% and 61%, respectively. With increasing survival after liver transplantation, the management of drug side effects in the late postoperative course becomes important.

Zusammenfassung:

Für viele chronische Lebererkrankungen und auch beim akuten Leberversagen ist eine Lebertransplantation die einzige kurative Therapie. In der Schweiz werden jährlich etwa 100 Lebertransplantationen durchgeführt. Beim akuten Leberversagen gelten die Clichy-Kriterien für die Transplantationsindikation. Bei einer Leberzirrhose hat die Transplantation ab einem MELD-Score von 15 einen günstigen Effekt auf das Langzeitüberleben. Das 5- und 10-Jahresüberleben nach Lebertransplantation beträgt 71% respektive 61%. Bei zunehmendem Langzeitüberleben wird das Management der Medikamentennebenwirkungen und kardiovaskulären Risiken immer wichtiger.

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Additional indexing

Other titles:Liver transplantation
Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Visceral and Transplantation Surgery
04 Faculty of Medicine > University Hospital Zurich > Clinic for Gastroenterology and Hepatology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2011
Deposited On:03 Mar 2012 12:32
Last Modified:05 Apr 2016 15:28
Publisher:Hans Huber
ISSN:0040-5930
Publisher DOI:10.1024/0040-5930/a000154
PubMed ID:21452144
Permanent URL: http://doi.org/10.5167/uzh-56916

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