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The BDNF Val66Met polymorphisms modulates sleep intensity: EEG frequency- and state-specificity


Bachmann, Valérie; Klein, Carina; Bodenmann, S; Schäfer, N; Berger, W; Brugger, P; Landolt, H P (2012). The BDNF Val66Met polymorphisms modulates sleep intensity: EEG frequency- and state-specificity. Sleep, 35(3):335-344.

Abstract

EEG slow waves are the hallmark of deep NREM sleep and may reflect the restorative functions of sleep. Evidence suggests that increased sleep slow waves after sleep deprivation reflect plastic synaptic processes, and that brain-derived neurotrophic factor (BDNF) is causally involved in their homeostatic regulation. The functional Val66Met polymorphism of the gene encoding pro-BDNF causes impaired activity-dependent secretion of mature BDNF protein. We investigated whether this polymorphism contributes to the pronounced inter-individual variation in sleep slow-away activity (SWA) in humans.

EEG slow waves are the hallmark of deep NREM sleep and may reflect the restorative functions of sleep. Evidence suggests that increased sleep slow waves after sleep deprivation reflect plastic synaptic processes, and that brain-derived neurotrophic factor (BDNF) is causally involved in their homeostatic regulation. The functional Val66Met polymorphism of the gene encoding pro-BDNF causes impaired activity-dependent secretion of mature BDNF protein. We investigated whether this polymorphism contributes to the pronounced inter-individual variation in sleep slow-away activity (SWA) in humans.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Pharmacology and Toxicology
04 Faculty of Medicine > Institute of Medical Molecular Genetics
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:3 September 2012
Deposited On:29 Jan 2012 14:57
Last Modified:05 Apr 2016 15:29
Publisher:Associated Professional Sleep Societies, LLC
ISSN:0161-8105
Free access at:Related URL. An embargo period may apply.
Publisher DOI:10.5665/sleep.1690
Related URLs:http://www.pharma.uzh.ch/research/chronobiology/areas/psychopharmacology/publications.html (Organisation)
http://www.journalsleep.org (Publisher)
PubMed ID:22379239
Permanent URL: http://doi.org/10.5167/uzh-57200

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