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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-57342

Singer, D; Camargo, S M R (2011). Collectrin and ACE2 in renal and intestinal amino acid transport. Channels, 5(5):410-423.

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Neutral amino acid transporters of the SLC6 family are expressed at the apical membrane of kidney and/or small intestine, where they (re-)absorb amino acids into the body. In this review we present the results concerning the dependence of their apical expression with their association to partner proteins. We will in particular focus on the situation of B0AT1 and B0AT3, that associate with members of the renin-angiotensin system (RAS), namely Tmem27 and angiotensin-converting enzyme 2 (ACE2), in a tissue specific manner. The role of this association in relation to the formation of a functional unit related to Na+ or amino acid transport will be assessed. We will conclude with some remarks concerning the relevance of this association to Hartnup disorder, where some mutations have been shown to differentially interact with the partner proteins.

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > Institute of Physiology
07 Faculty of Science > Institute of Physiology

04 Faculty of Medicine > Center for Integrative Human Physiology
DDC:570 Life sciences; biology
610 Medicine & health
Deposited On:31 Jan 2012 20:11
Last Modified:13 Jul 2014 12:05
Publisher:Landes Bioscience
Publisher DOI:10.4161/chan.5.5.16470
PubMed ID:21814048
Citations:Web of Science®. Times Cited: 4
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