Quick Search:

uzh logo
Browse by:

Zurich Open Repository and Archive

Maintenance: Tuesday, July the 26th 2016, 07:00-10:00

ZORA's new graphical user interface will be relaunched (For further infos watch out slideshow ZORA: Neues Look & Feel). There will be short interrupts on ZORA Service between 07:00am and 10:00 am. Please be patient.

Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-57349

Vinogradov, S N; Hoogewijs, D; Vanfleteren, J; Dewilde, S; Moens, L; Hankeln, T (2011). Evolution of the globin superfamily and its function. In: Nagai, M. Hemoglobin: recent development and topics. Kerala, IND: Research Signpost, 231-254.

[img]Published Version
PDF - Repository staff only


Bacterial hemoglobins (Hbs) are ancient proteins, found
in approximately two thirds of presently known bacterial genomes (>800), clearly related to the familiar vertebrate myoglobins,α- and β-globins and the recently discovered neuroglobins and cytoglobins. All bacterial Hbs belong to one of three families: the flavohemoglobins (F) and sensor (S) globins, that display the canonical 3/3 α-helical fold characteristic of the metazoan Hbs, and the 2/2 (“truncated”) Hbs (T), that exhibit a shortened 2/2
α-helical fold. The F family comprises single domain globins and chimeric, -400aa proteins with C-terminal ferredoxin reductase-like domain. The S family consists of single domain globins and chimeric proteins with variable (300-700aa) C-terminal domain(s)involved in chemotaxis and gene regulation. Because eukaryote globins appear to be most similar to members of the bacterial F family, we have proposed that one or more horizontal transfer(s)
of single domain FHb-like gene(s) to ancestor(s) of multicellular eukaryotes could have accompanied the endosymbiotic events responsible for the origins of mitochondria and plastids, and provided the
precursor(s) of all the eukaryote Hbs, at some time prior to the emergence of multicellularity, about 1,000 to 650 Myrs ago. Within this framework, the probable early bacterial Hb functions, oxygen binding and sensing and enzymatic reactions with nitric oxide, were preserved in bacteria and eukaryotes. The emergence of multicellularity and the evolution of crown eukaryotes (plants,
fungi and metazoans) and numerous unicellular eukaryote groups, was accompanied by an expansion and diversification of globin functions, mostly not well understood at present. Apart from reversible oxygen binding, enabling
control of oxygen concentration and the storage and transport of oxygen, these include NO dioxygenase and nitrite reductase activities, oxygen sensing,
reactions with free radicals and specific adaptations exemplified by reversible sulfide binding and transport and chloroperoxidase activity. Because multicellularity emerged more than once, it is likely that each event was
accompanied by differential spreading of the three globin families in eukaryotes, resulting in the selection of globins best suited to assist in the survival of the
emerging eukaryote. Of the three bacterial globin families, the S and T families spread only to the fungi and plants, respectively, and some unicellular eukaryotes.
In contrast, the single domain globins from the F family spread widely among eukaryotes, particularly the crown eukaryotes, likely due to the plasticity of their
structures that allowed subtle diversification of their functions. Overall, the globin superfamily has displayed unsuspected versatility and extraordinary success in
evolving from useful but dispensable proteins in a majority of prokaryotes, to ubiquitous indispensability in the crown eukaryotes.



1 download since deposited on 27 Jan 2012
0 downloads since 12 months

Detailed statistics

Additional indexing

Item Type:Book Section, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > Institute of Physiology
07 Faculty of Science > Institute of Physiology

04 Faculty of Medicine > Center for Integrative Human Physiology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Deposited On:27 Jan 2012 22:25
Last Modified:05 Apr 2016 15:30
Publisher:Research Signpost

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page