Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-57389
Rämer, P C; Chijioke, O; Meixlsperger, S; Leung, C S; Münz, C (2011). Mice with human immune system components as in vivo models for infections with human pathogens. Immunology and Cell Biology, 89(3):408-416.
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Many pathogens relevant to human disease do not infect other animal species. Therefore, animal models that reconstitute or harbor human tissues are explored as hosts for these. In this review, we will summarize recent advances to utilize mice with human immune system components, reconstituted from hematopoietic progenitor cells in vivo. Such mice can be used to study human pathogens that replicate in leukocytes. In addition to studying the replication of these pathogens, the reconstituted human immune system components can also be analyzed for initiating immune responses and control against these infections. Moreover, these new animal models of human infectious disease should replicate the reactivity of the human immune system to vaccine candidates and, especially, the adjuvants contained in them, more faithfully.
|Item Type:||Journal Article, refereed, further contribution|
|Communities & Collections:||04 Faculty of Medicine > University Hospital Zurich > Institute of Experimental Immunology|
|DDC:||570 Life sciences; biology|
610 Medicine & health
|Deposited On:||29 Jan 2012 20:51|
|Last Modified:||01 Dec 2013 05:40|
|Publisher:||Nature Publishing Group|
|Additional Information:||Comment in: Immunol Cell Biol. 2011 Mar;89(3):330-331|
|Citations:||Web of Science®. Times Cited: 17|
Scopus®. Citation Count: 16
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