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Mice with human immune system components as in vivo models for infections with human pathogens


Rämer, P C; Chijioke, O; Meixlsperger, S; Leung, C S; Münz, C (2011). Mice with human immune system components as in vivo models for infections with human pathogens. Immunology and Cell Biology, 89(3):408-416.

Abstract

Many pathogens relevant to human disease do not infect other animal species. Therefore, animal models that reconstitute or harbor human tissues are explored as hosts for these. In this review, we will summarize recent advances to utilize mice with human immune system components, reconstituted from hematopoietic progenitor cells in vivo. Such mice can be used to study human pathogens that replicate in leukocytes. In addition to studying the replication of these pathogens, the reconstituted human immune system components can also be analyzed for initiating immune responses and control against these infections. Moreover, these new animal models of human infectious disease should replicate the reactivity of the human immune system to vaccine candidates and, especially, the adjuvants contained in them, more faithfully.

Many pathogens relevant to human disease do not infect other animal species. Therefore, animal models that reconstitute or harbor human tissues are explored as hosts for these. In this review, we will summarize recent advances to utilize mice with human immune system components, reconstituted from hematopoietic progenitor cells in vivo. Such mice can be used to study human pathogens that replicate in leukocytes. In addition to studying the replication of these pathogens, the reconstituted human immune system components can also be analyzed for initiating immune responses and control against these infections. Moreover, these new animal models of human infectious disease should replicate the reactivity of the human immune system to vaccine candidates and, especially, the adjuvants contained in them, more faithfully.

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24 citations in Web of Science®
23 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > Institute of Experimental Immunology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:February 2011
Deposited On:29 Jan 2012 20:51
Last Modified:05 Apr 2016 15:30
Publisher:Nature Publishing Group
ISSN:0818-9641
Additional Information:Comment in: Immunol Cell Biol. 2011 Mar;89(3):330-331
Publisher DOI:10.1038/icb.2010.151
PubMed ID:21301484
Permanent URL: http://doi.org/10.5167/uzh-57389

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