Quick Search:

uzh logo
Browse by:

Zurich Open Repository and Archive

Maintenance: Tuesday, July the 26th 2016, 07:00-10:00

ZORA's new graphical user interface will be relaunched (For further infos watch out slideshow ZORA: Neues Look & Feel). There will be short interrupts on ZORA Service between 07:00am and 10:00 am. Please be patient.

Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-57389

Rämer, P C; Chijioke, O; Meixlsperger, S; Leung, C S; Münz, C (2011). Mice with human immune system components as in vivo models for infections with human pathogens. Immunology and Cell Biology, 89(3):408-416.

Published Version
PDF (Article in press)
View at publisher


Many pathogens relevant to human disease do not infect other animal species. Therefore, animal models that reconstitute or harbor human tissues are explored as hosts for these. In this review, we will summarize recent advances to utilize mice with human immune system components, reconstituted from hematopoietic progenitor cells in vivo. Such mice can be used to study human pathogens that replicate in leukocytes. In addition to studying the replication of these pathogens, the reconstituted human immune system components can also be analyzed for initiating immune responses and control against these infections. Moreover, these new animal models of human infectious disease should replicate the reactivity of the human immune system to vaccine candidates and, especially, the adjuvants contained in them, more faithfully.


24 citations in Web of Science®
23 citations in Scopus®
Google Scholar™



66 downloads since deposited on 29 Jan 2012
19 downloads since 12 months

Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > Institute of Experimental Immunology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Date:February 2011
Deposited On:29 Jan 2012 20:51
Last Modified:05 Apr 2016 15:30
Publisher:Nature Publishing Group
Additional Information:Comment in: Immunol Cell Biol. 2011 Mar;89(3):330-331
Publisher DOI:10.1038/icb.2010.151
PubMed ID:21301484

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page