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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-57392

Chijioke, O; Münz, C (2011). Interactions of human myeloid cells with natural killer cell subsets in vitro and in vivo. Journal of Biomedicine and Biotechnology, 2011:251679.

Published Version


In both human and mouse it has been recently realized that natural killer (NK) cells do not emerge from the bone marrow with full functional competence but rather acquire functions in interaction with antigen-presenting cells (APCs), primarily dendritic cells (DCs). Here we review the mechanisms and the consequences of this NK-cell preactivation, as well as discuss new experimental models that now allow investigating these interactions for human NK cells and their response to human pathogens in vivo. These investigations will allow harnessing NK cells during vaccination for improved innate and adaptive immunity.

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Institute of Experimental Immunology
DDC:570 Life sciences; biology
610 Medicine & health
Date:March 2011
Deposited On:29 Jan 2012 20:43
Last Modified:21 Dec 2013 03:36
Publisher:Hindawi Publishing Corporation
Publisher DOI:10.1155/2011/251679
PubMed ID:21541250
Citations:Web of Science®. Times Cited: 5
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Scopus®. Citation Count: 6

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