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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-57394

Münz, C (2011). Macroautophagy during innate immune activation. Frontiers in Microbiology, 2:72.

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Innate immune activation is initiated by recognition of pathogen associated molecular patterns (PAMPs). Delivery of PAMPs to their respective receptors, regulation of receptor activity, and effector functions downstream from these receptors, which constitute part of the initiated innate immune control, are in part mediated via macroautophagy, an evolutionary conserved pathway for cytoplasmic constituent degradation in lysosomes. In this review these facets of the recently unveiled involvement of macroautophagy in innate immunity will be summarized, and aspects that need additional investigations will be high-lighted. The improved understanding of the capabilities of macroautophagy for immunity suggests that this pathway should be harnessed in immunotherapies against infectious diseases.

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Institute of Experimental Immunology
DDC:570 Life sciences; biology
610 Medicine & health
Deposited On:29 Jan 2012 19:41
Last Modified:06 Dec 2012 01:17
Publisher:Frontiers Research Foundation
Additional Information:This Document is protected by copyright and was first published by Frontiers. All rights reserved. It is reproduced with permission.
Publisher DOI:10.3389/fmicb.2011.00072
PubMed ID:21747792
Citations:Web of Science®. Times Cited: 5
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Scopus®. Citation Count: 7

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