Quick Search:

uzh logo
Browse by:
bullet
bullet
bullet
bullet

Zurich Open Repository and Archive 

Hédou, G; Pryce, C; Di Iorio, L; Heidbreder, C A; Feldon, J (2001). An automated analysis of rat behavior in the forced swim test. Pharmacology Biochemistry and Behavior, 70(1):65-76.

Full text not available from this repository.

Abstract

The Porsolt forced swim test (FST) is a commonly used paradigm to evaluate antidepressant activity of drugs. This test is based on visual measurement of the rat's floating time (FT) in a tank filled with water. Here, we present an automated, accurate and faster method for estimating FT by the distance moved (DM) by the animal via the use of the Ethovision software in three separate experiments. Experiment 1 investigated the effect of varying delays (24-h and 7-day) between pretest and test on FT and DM. Experiment 2 aimed at examining the effects of a 2-day withdrawal period in rats sensitized to amphetamine and cocaine, on FT and DM. Finally, Experiment 3 looked at the effects of desipramine and fluoxetine on FT and DM. The results of these experiments show that increasing the delay between pretest and test reduced FT during subsequent exposure (test). In addition, rats sensitized to and then withdrawn from either amphetamine or cocaine did not differ in FT or DM compared with control rats. Finally, both desipramine and fluoxetine reduced FT and increased DM. Furthermore, DM was consistently significantly negatively correlated with FT. These results support the use of an automated method for the evaluation of rat behavior in FST.

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Institute of Zoology (former)
DDC:570 Life sciences; biology
590 Animals (Zoology)
Language:English
Date:1 September 2001
Deposited On:11 Feb 2008 12:16
Last Modified:27 Nov 2013 19:38
Publisher:Elsevier
ISSN:0091-3057
Publisher DOI:10.1016/S0091-3057(01)00575-5
PubMed ID:11566143
Citations:Web of Science®. Times Cited: 27
Google Scholar™
Scopus®. Citation Count: 32

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page