UZH-Logo

Optimizing the use of alkylators in neuro-oncology


Perry, J R; Wick, W; Weller, M (2011). Optimizing the use of alkylators in neuro-oncology. Educational Book, 2001:61-64.

Abstract

For more than three decades, alkylating agents have been the most widely used class of chemotherapeutic agents for the treatment of glial brain tumors. Today, concomitant and adjuvant temozolomide is the standard of care for newly diagnosed glioblastoma. Temozolomide alone or in combination with radiotherapy is being explored in ongoing trials in newly diagnosed patients with low-grade and anaplastic glioma. Rechallenge with alternative dosing schedules of temozolomide is a valid treatment option in recurrent, temozolomide-pretreated patients with glioblastoma, and nitrosourea compounds are alternative treatment options in this setting, in addition to novel, mostly antiangiogenic agents, notably bevacizumab. Moreover, nitrosoureas have become the gold standard comparator arm for the evaluation of novel treatments in recurrent glioblastoma.

For more than three decades, alkylating agents have been the most widely used class of chemotherapeutic agents for the treatment of glial brain tumors. Today, concomitant and adjuvant temozolomide is the standard of care for newly diagnosed glioblastoma. Temozolomide alone or in combination with radiotherapy is being explored in ongoing trials in newly diagnosed patients with low-grade and anaplastic glioma. Rechallenge with alternative dosing schedules of temozolomide is a valid treatment option in recurrent, temozolomide-pretreated patients with glioblastoma, and nitrosourea compounds are alternative treatment options in this setting, in addition to novel, mostly antiangiogenic agents, notably bevacizumab. Moreover, nitrosoureas have become the gold standard comparator arm for the evaluation of novel treatments in recurrent glioblastoma.

Downloads

52 downloads since deposited on 29 Jan 2012
9 downloads since 12 months
Detailed statistics

Additional indexing

Item Type:Journal Article, not refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Neurology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2011
Deposited On:29 Jan 2012 11:37
Last Modified:05 Apr 2016 15:31
Publisher:American Society of Clinical Oncology
Series Name:Educational Book
ISSN:1548-8748
Additional Information:Kongressbeitrag anlässlich des 2011 ASCO Annual Meeting, June 3 - 7, 2011, Chicago, Ill.
Official URL:http://www.asco.org/ASCOv2/Education+%26+Training/Educational+Book?&vmview=edbk_detail_view&confID=102&abstractID=1046
Related URLs:http://www.asco.org/ASCOv2/Education+%26+Training/Educational+Book (Publisher)
http://chicago2011.asco.org/ (Organisation)
Permanent URL: http://doi.org/10.5167/uzh-57536

Download

[img]
Preview
Content: Published Version
Filetype: PDF
Size: 73kB

TrendTerms

TrendTerms displays relevant terms of the abstract of this publication and related documents on a map. The terms and their relations were extracted from ZORA using word statistics. Their timelines are taken from ZORA as well. The bubble size of a term is proportional to the number of documents where the term occurs. Red, orange, yellow and green colors are used for terms that occur in the current document; red indicates high interlinkedness of a term with other terms, orange, yellow and green decreasing interlinkedness. Blue is used for terms that have a relation with the terms in this document, but occur in other documents.
You can navigate and zoom the map. Mouse-hovering a term displays its timeline, clicking it yields the associated documents.

Author Collaborations