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Fransen, J; Johnson, S R; van den Hoogen, F; Baron, M; Allanore, Y; Carreira, P E; Czirják, L; Denton, C P; Distler, O; Furst, D E; Gabrielli, A; Herrick, A; Inanc, M; Kahaleh, B; Kowal-Bielecka, O; Medsger, T A; Mueller-Ladner, U; Riemekasten, G; Sierakowski, S; Valentini, G; Veale, D; Vonk, M C; Walker, U; Chung, L; Clements, P J; Collier, D H; Csuka, M E; Jimenez, S; Merkel, P A; Seibold, J R; Silver, R; Steen, V; Tyndall, A; Matucci-Cerinic, M; Pope, J E; Khanna, D (2012). Items for developing revised classification criteria in systemic sclerosis: Results of a consensus exercise with the ACR/EULAR working committee for classification criteria in systemic sclerosis. Arthritis Care and Research, 64(3):351-357.

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Abstract

BACKGROUND: Classification criteria for systemic sclerosis (SSc) are being updated. OBJECTIVE: To select a set of items potentially useful for the classification of SSc using consensus procedures including the Delphi and nominal group techniques (NGT). METHODS: Items were identified through two independent consensus exercises performed by the Scleroderma Clinical Trials Consortium (SCTC) and the EULAR Scleroderma Trials and Research Group (EUSTAR). The first-round items from both exercises were collated and redundancies were removed leaving 168 items. A 3-round Delphi exercise was performed using a 1-9 scale (1=completely inappropriate and 9=completely appropriate) and a consensus meeting using NGT. During the last Delphi, the items were ranked on a 1-10 scale. RESULTS: Round 1: 106 experts rated the 168 items. Those with a median score <4 were removed, resulting in a list of 102 items. Round 2: The items were again rated for appropriateness and subjected to a consensus meeting using NGT by European and North American SSc experts (n=16), resulting in 23 items. Round 3: SSc experts (n=26) then individually scored each of the 23 items in a last Delphi round, using an appropriateness score (1-9) and ranking their 10 most appropriate items for classification of SSc. Presence of skin thickening, SSc-specific autoantibodies, abnormal nailfold capillary pattern and Raynaud's phenomenon ranked highest in the final list that also included items indicating internal organ involvement. CONCLUSION: The Delphi exercise and NGT resulted in a set of 23 items for classification of SSc which will be assessed for their discriminative properties in a prospective study. © 2011 by the American College of Rheumatology.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Rheumatology Clinic and Institute of Physical Medicine
DDC:610 Medicine & health
Language:English
Date:2012
Deposited On:29 Jan 2012 19:06
Last Modified:27 Nov 2013 23:37
Publisher:Wiley-Blackwell
ISSN:2151-464X
Publisher DOI:10.1002/acr.20679
PubMed ID:22052558

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