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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-57591

Kelly, B J; Diefenbach, E; Fraefel, C; Diefenbach, R J (2012). Identification of host cell proteins which interact with herpes simplex virus type 1 tegument protein pUL37. Biochemical and Biophysical Research Communications (BBRC), 417(3):961-965.

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Abstract

The herpes simplex virus type 1 (HSV-1) structural tegument protein pUL37, which is conserved across the Herpesviridae family, is known to be essential for secondary envelopment during the egress of viral particles. To shed light on additional roles of pUL37 during viral replication a yeast two-hybrid screen of a human brain cDNA library was undertaken. This screen identified ten host cell proteins as potential pUL37 interactors. One of the interactors, serine threonine kinase TAOK3, was subsequently confirmed to interact with pUL37 using an in vitro pulldown assay. Such host cell/pUL37 interactions provide further insights into the multifunctional role of this herpesviral tegument protein.

Item Type:Journal Article, refereed, original work
Communities & Collections:05 Vetsuisse Faculty > Institute of Virology
DDC:570 Life sciences; biology
Language:English
Date:19 December 2012
Deposited On:02 Mar 2012 13:52
Last Modified:11 Dec 2013 02:59
Publisher:Elsevier
ISSN:0006-291X
Publisher DOI:10.1016/j.bbrc.2011.12.044
PubMed ID:22202175
Citations:Web of Science®. Times Cited: 3
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