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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-57621

Jenny, C; Biallas, M; Trajkovic, I; Fauchère, J C; Bucher, H U; Wolf, M (2011). Reproducibility of cerebral tissue oxygen saturation measurements by near-infrared spectroscopy in newborn infants. Journal of Biomedical Optics, 16(9):097004.

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Early detection of cerebral hypoxemia is an important aim in neonatology. A relevant parameter to assess brain oxygenation may be the cerebral tissue oxygen saturation (StO(2)) measured by near-infrared spectroscopy (NIRS). So far the reproducibility of StO(2) measurements was too low for clinical application, probably due to inhomogeneities. The aim of this study was to test a novel sensor geometry which reduces the influence of inhomogeneities. Thirty clinically stable newborn infants, with a gestational age of median 33.9 (range 26.9 to 41.9) weeks, birth weight of 2220 (820 to 4230) g, postnatal age of 5 (1 to 71) days were studied. At least four StO(2) measurements of 1 min duration were carried out using NIRS on the lateral head. The sensor was repositioned between measurements. Reproducibility was calculated by a linear mixed effects model. The mean StO(2) was 79.99 ± 4.47% with a reproducibility of 2.76% and a between-infant variability of 4.20%. Thus, the error of measurement only accounts for 30.1% of the variability. The novel sensor geometry leads to considerably more precise measurements compared to previous studies with, e.g., ∼5% reproducibility for the NIRO 300. The novel StO(2) values hence have a higher clinical relevance.


9 citations in Web of Science®
11 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Neonatology
Dewey Decimal Classification:610 Medicine & health
Deposited On:31 Jan 2012 18:08
Last Modified:05 Apr 2016 15:31
Publisher:Society of Photo-Optical Instrumentation Engineers (SPIE)
Additional Information:Copyright 2012 Society of Photo-Optical Instrumentation Engineers. This paper was published in J Biomed Opt. 2011 Sep;16(9):097004 and is made available as an electronic reprint with permission of SPIE. One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited.
Publisher DOI:10.1117/1.3622756
PubMed ID:21950939

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