Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-57634
Kempf, W; Pfaltz, K; Vermeer, M H; Cozzio, A; Ortiz-Romero, P L; Bagot, M; Olsen, E; Kim, Y H; Dummer, R; Pimpinelli, N; Whittaker, S; Hodak, E; Cerroni, L; Berti, E; Horwitz, S; Prince, H M; Guitart, J; Estrach, T; Sanches, J A; Duvic, M; Ranki, A; Dreno, B; Ostheeren-Michaelis, S; Knobler, R; Wood, G; Willemze, R (2011). EORTC, ISCL, and USCLC consensus recommendations for the treatment of primary cutaneous CD30-positive lymphoproliferative disorders: lymphomatoid papulosis and primary cutaneous anaplastic large-cell lymphoma. Blood, 118(15):218-225.
Primary cutaneous CD30(+) lymphoproliferative disorders (CD30(+) LPDs) are the second most common form of cutaneous T-cell lymphomas and include lymphomatoid papulosis and primary cutaneous anaplastic large-cell lymphoma. Despite the anaplastic cytomorphology of tumor cells that suggest an aggressive course, CD30(+) LPDs are characterized by an excellent prognosis. Although a broad spectrum of therapeutic strategies has been reported, these have been limited mostly to small retrospective cohort series or case reports, and only very few prospective controlled or multicenter studies have been performed, which results in a low level of evidence for most therapies. The response rates to treatment, recurrence rates, and outcome have not been analyzed in a systematic review. Moreover, international guidelines for staging and treatment of CD30(+) LPDs have not yet been presented. Based on a literature analysis and discussions, recommendations were elaborated by a multidisciplinary expert panel of the Cutaneous Lymphoma Task Force of the European Organization for Research and Treatment of Cancer, the International Society for Cutaneous Lymphomas, and the United States Cutaneous Lymphoma Consortium. The recommendations represent the state-of-the-art management of CD30(+) LPDs and include definitions for clinical endpoints as well as response criteria for future clinical trials in CD30(+) LPDs.
|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||04 Faculty of Medicine > University Hospital Zurich > Dermatology Clinic|
|DDC:||610 Medicine & health|
|Deposited On:||12 Feb 2012 12:00|
|Last Modified:||29 Nov 2012 15:10|
|Publisher:||American Society of Hematology|
|ISSN:||0006-4971 (P) 1528-0020 (E)|
|Additional Information:||This research was originally published in Blood. Blood. 2011 Oct 13;118(15):4024-35. Copyright by the American Society of Hematology.|
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