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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-5771

Althaus, F R (2005). Poly(ADP-ribose): a co-regulator of DNA methylation? Oncogene, 24(1):11-12.

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The formation of multiprotein complexes is l'ordre du jour in regulatory pathways. In this issue of Oncogene, Reale et al. report the formation of a particularly sophisticated complex of two important regulatory enzymes, DNMT1 (DNA methyltransferase-1) and PARP-1 (poly(ADP-ribose)polymerase-1). The former evolved with a specific sequence motif binding the enzymatic product of the latter. The product, poly(ADP-ribose), bonds the two partners into a heterodimeric complex and, as a consequence, the catalytic function of DNMT1 is silenced. Thus, PARP-1 becomes a conditional negative regulator of DNMT1. In a larger perspective, Reale et al. highlight the potential role of PARP-1 as a co-regulator of DNA methylation leading to epigenetic reprogramming of cancer cells.


10 citations in Web of Science®
17 citations in Scopus®
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60 downloads since deposited on 27 Mar 2009
16 downloads since 12 months

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:05 Vetsuisse Faculty > Institute of Veterinary Pharmacology and Toxicology
Dewey Decimal Classification:570 Life sciences; biology
Date:6 January 2005
Deposited On:27 Mar 2009 14:47
Last Modified:05 Apr 2016 12:35
Publisher:Nature Publishing Group
Publisher DOI:10.1038/sj.onc.1208382
Official URL:http://www.nature.com/onc/journal/v24/n1/pdf/1208382a.pdf
PubMed ID:15637586

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