Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-5771
Althaus, F R (2005). Poly(ADP-ribose): a co-regulator of DNA methylation? Oncogene, 24(1):11-12.
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The formation of multiprotein complexes is l'ordre du jour in regulatory pathways. In this issue of Oncogene, Reale et al. report the formation of a particularly sophisticated complex of two important regulatory enzymes, DNMT1 (DNA methyltransferase-1) and PARP-1 (poly(ADP-ribose)polymerase-1). The former evolved with a specific sequence motif binding the enzymatic product of the latter. The product, poly(ADP-ribose), bonds the two partners into a heterodimeric complex and, as a consequence, the catalytic function of DNMT1 is silenced. Thus, PARP-1 becomes a conditional negative regulator of DNMT1. In a larger perspective, Reale et al. highlight the potential role of PARP-1 as a co-regulator of DNA methylation leading to epigenetic reprogramming of cancer cells.
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|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||05 Vetsuisse Faculty > Institute of Veterinary Pharmacology and Toxicology|
|Dewey Decimal Classification:||570 Life sciences; biology|
|Date:||6 January 2005|
|Deposited On:||27 Mar 2009 14:47|
|Last Modified:||27 Nov 2013 23:37|
|Publisher:||Nature Publishing Group|
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