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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-5772

Baumgartel, K; Genoux , D; Welzl, H; Tweedie-Cullen, R Y; Koshibu, K; Livingstone-Zatchej, M; Mamie, C; Mansuy, I M (2008). Control of the establishment of aversive memory by calcineurin and Zif268. Nature Neuroscience, 11(5):572-578.

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Abstract

Emotional memory is a rapidly acquired and persistent form of memory, and its robustness is in part determined by the initial strength of the memory. Here, we provide new evidence that the protein phosphatase calcineurin (CaN), a potent negative regulator of neuronal signaling that is known to constrain learning and memory, critically regulates the establishment of emotional memory through mechanisms involving the immediate early gene Zif268 (also known as Egr1). We found that CaN is inhibited in the amygdala during the establishment of aversive memory, but Zif268 is activated. Using inducible transgenesis in mice, we further saw that CaN inhibition and Zif268 overexpression during memory establishment strengthen the memory trace and enhance its resistance to extinction. We found that CaN inhibition correlates with increased Zif268 expression and that a common pool of proteins is regulated in the amygdala after CaN inhibition and Zif268 overexpression. Together, these findings reveal a previously unknown mechanism for the control of emotional memory that depends on CaN and Zif268.

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57 citations in Web of Science®
63 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Brain Research Institute
04 Faculty of Medicine > Institute of Anatomy
DDC:570 Life sciences; biology
610 Medicine & health
Language:English
Date:1 May 2008
Deposited On:19 Nov 2008 16:31
Last Modified:23 Nov 2012 13:39
Publisher:Nature Publishing Group
ISSN:1097-6256
Publisher DOI:doi:10.1038/nn.2113
PubMed ID:18425121

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