Quick Search:

uzh logo
Browse by:
bullet
bullet
bullet
bullet

Zurich Open Repository and Archive

Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-5773

Ben Abdallah, N M; Slomianka, L; Vyssotski, A L; Lipp, H P (2010). Early age-related changes in adult hippocampal neurogenesis in C57 mice. Neurobiology of Aging, 31(1):151-161.

[img] PDF - Registered users only
1MB

View at publisher

Abstract

Strong age-related declines in conjunction with comparatively easy experimental manipulations of adult hippocampal neurogenesis have generated considerable public and scientific interest in the prospect of “new neurons for old brains”. Only few studies addressed the time course of the natural changes, which are the substrate for interventions that may realize this prospect. We provide a monthly or bimonthly account of cell proliferation, neurogenesis and cell death during the first 9 months of the life of C57Bl/6J mice. Ki67- and DCX-positive cell numbers declined exponentially without an intermittent plateau (∼40% per month). Cell death in relation to cell proliferation was lowest at 1 month, increased at 2 months to remain constant until 4 months, and decreased again at 5 months to remain stable until 9 months. Granule cell number did not change with age. Our results suggest that manipulations of proliferation and neurogenesis may, at any time, interact with strong natural changes of these processes. Mediators of their age-related decline may be studied over periods much shorter than those typically used.

Citations

66 citations in Web of Science®
73 citations in Scopus®
Google Scholar™

Altmetrics

Downloads

1 download since deposited on 20 Nov 2008
0 downloads since 12 months

Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Anatomy
DDC:570 Life sciences; biology
610 Medicine & health
Language:English
Date:January 2010
Deposited On:20 Nov 2008 08:02
Last Modified:22 Feb 2014 12:35
Publisher:Elsevier
ISSN:0197-4580
Publisher DOI:10.1016/j.neurobiolaging.2008.03.002
PubMed ID:18455269

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page