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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-57943

Hagenmuller, F; Hitz, K; Darvas, F; Kawohl, W (2011). Determination of the loudness dependence of auditory evoked potentials: single-electrode estimation versus dipole source analysis. Human Psychopharmacology: Clinical and Experimental, 26(2):147-154.

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The loudness dependence of auditory evoked potentials (LDAEP) has been described as a measure of central serotonergic activity. Single-electrode estimation and dipole source analysis (DSA) are the most utilized methods for the estimation of LDAEP. To date, it is assumed that both methods are equally reliable. Nevertheless, according to our knowledge, the advantage of either method has not yet been shown directly. The aim of our study was to compare single-electrode estimation and dipole source analysis in the determination of the LDAEP.

Tones of five different intensities were presented binaurally to 10 healthy volunteers. Amplitudes of N1/P2 and LDAEP were determined at the central electrode site referenced to average and to linked mastoids and with DSA in the left and the right hemispheres. Scores were normalized (z-scores), compared, and correlated.

Contrary to our expectations, we found a significant difference between scores obtained with single-electrode estimation and with DSA.

The difference may be caused by confounding activation of a frontal source in the single-electrode method. The single-electrode approach cannot be equated with DSA in the determination of the LDAEP. This should be considered when comparing the results of different LDAEP studies using only one of these methods.


9 citations in Web of Science®
9 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Psychiatric University Hospital Zurich > Clinic for Clinical and Social Psychiatry Zurich West (former)
Dewey Decimal Classification:610 Medicine & health
Deposited On:06 Mar 2012 10:32
Last Modified:05 Apr 2016 15:32
Publisher DOI:10.1002/hup.1186

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