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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-58186

Gerondakis, S; Grumont, R; Gugasyan, R; Wong, W W L; Isomura, I; Ho, W; Banerjee, A (2006). Unravelling the complexities of the NF-κB signalling pathway using mouse knockout and transgenic models. Oncogene, 25(51):6781-6799.

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Abstract

The nuclear factor-jB (NF-jB) signalling pathway serves a crucial role in regulating the transcriptional responses of physiological processes that include cell division, cell survival, differentiation, immunity and inflammation. Here we outline studies using mouse models in which the core components of the NF-jB pathway, namely the IjB kinasesubunits(IKKa,IKKbandNEMO),theIjB proteins(IjBa,IjBb,IjBeandBcl-3)andthefiveNF-jB transcription factors (NF-jB1, NF-jB2, c-Rel, RelA and RelB),havebeengeneticallymanipulatedusingtransgenic andknockouttechnology.

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Institute of Experimental Immunology
DDC:570 Life sciences; biology
610 Medicine & health
Language:English
Date:2006
Deposited On:19 Jun 2012 16:18
Last Modified:08 Dec 2013 19:11
Publisher:Nature Publishing Group
ISSN:0950-9232 (P) 1476-5594 (E)
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:10.1038/sj.onc.1209944
Citations:Web of Science®. Times Cited: 127
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