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Unravelling the complexities of the NF-κB signalling pathway using mouse knockout and transgenic models


Gerondakis, S; Grumont, R; Gugasyan, R; Wong, W W L; Isomura, I; Ho, W; Banerjee, A (2006). Unravelling the complexities of the NF-κB signalling pathway using mouse knockout and transgenic models. Oncogene, 25(51):6781-6799.

Abstract

The nuclear factor-jB (NF-jB) signalling pathway serves a crucial role in regulating the transcriptional responses of physiological processes that include cell division, cell survival, differentiation, immunity and inflammation. Here we outline studies using mouse models in which the core components of the NF-jB pathway, namely the IjB kinasesubunits(IKKa,IKKbandNEMO),theIjB proteins(IjBa,IjBb,IjBeandBcl-3)andthefiveNF-jB transcription factors (NF-jB1, NF-jB2, c-Rel, RelA and RelB),havebeengeneticallymanipulatedusingtransgenic andknockouttechnology.

The nuclear factor-jB (NF-jB) signalling pathway serves a crucial role in regulating the transcriptional responses of physiological processes that include cell division, cell survival, differentiation, immunity and inflammation. Here we outline studies using mouse models in which the core components of the NF-jB pathway, namely the IjB kinasesubunits(IKKa,IKKbandNEMO),theIjB proteins(IjBa,IjBb,IjBeandBcl-3)andthefiveNF-jB transcription factors (NF-jB1, NF-jB2, c-Rel, RelA and RelB),havebeengeneticallymanipulatedusingtransgenic andknockouttechnology.

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > Institute of Experimental Immunology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:2006
Deposited On:19 Jun 2012 14:18
Last Modified:05 Apr 2016 15:33
Publisher:Nature Publishing Group
ISSN:0950-9232 (P) 1476-5594 (E)
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:10.1038/sj.onc.1209944
Permanent URL: http://doi.org/10.5167/uzh-58186

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