Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-58186
Gerondakis, S; Grumont, R; Gugasyan, R; Wong, W W L; Isomura, I; Ho, W; Banerjee, A (2006). Unravelling the complexities of the NF-κB signalling pathway using mouse knockout and transgenic models. Oncogene, 25(51):6781-6799.
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Abstract
The nuclear factor-jB (NF-jB) signalling pathway serves a crucial role in regulating the transcriptional responses of physiological processes that include cell division, cell survival, differentiation, immunity and inflammation. Here we outline studies using mouse models in which the core components of the NF-jB pathway, namely the IjB kinasesubunits(IKKa,IKKbandNEMO),theIjB proteins(IjBa,IjBb,IjBeandBcl-3)andthefiveNF-jB transcription factors (NF-jB1, NF-jB2, c-Rel, RelA and RelB),havebeengeneticallymanipulatedusingtransgenic andknockouttechnology.
| Item Type: | Journal Article, refereed, further contribution |
|---|---|
| Communities & Collections: | 04 Faculty of Medicine > University Hospital Zurich > Institute of Experimental Immunology |
| DDC: | 570 Life sciences; biology 610 Medicine & health |
| Language: | English |
| Date: | 2006 |
| Deposited On: | 19 Jun 2012 16:18 |
| Last Modified: | 21 Jan 2013 23:39 |
| Publisher: | Nature Publishing Group |
| ISSN: | 0950-9232 (P) 1476-5594 (E) |
| Free access at: | Publisher DOI. An embargo period may apply. |
| Publisher DOI: | 10.1038/sj.onc.1209944 |
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