Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-58189
Wong, W W L; Puthalakath, H (2008). Bcl-2 family proteins: The sentinels of the mitochondrial apoptosis pathway. IUBMB Life, 60(6):390-397.
|Published Version (English)|
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Bcl-2 family members are the arbiters of mitochondrial apo- ptotic pathway, which is conserved through evolution. The stoi- chiometry of pro- versus antiapoptotic Bcl-2 family members in the cell determines whether the cell lives or dies. This fine bal- ance is regulated at the transcriptional or posttranslational level in response to various cellular cues. These signals are transmit- ted through the upstream molecules in the pathway, that is, the BH3-only molecules that results in the activation of the adaptor molecules, Bax and Bak, at the mitochondrial surface ensuing mitochondrial dysfunction and apoptosis. Understanding the activation process offers a great potential in the therapeutic intervention of many diseases such as cancer and autoimmune disorders.
|Item Type:||Journal Article, refereed, further contribution|
|Communities & Collections:||04 Faculty of Medicine > University Hospital Zurich > Institute of Experimental Immunology|
|DDC:||570 Life sciences; biology
610 Medicine & health
|Deposited On:||19 Jun 2012 14:22|
|Last Modified:||20 Dec 2013 23:04|
|Free access at:||Publisher DOI. An embargo period may apply.|
|Citations:||Web of Science®. Times Cited: 63|
Scopus®. Citation Count: 74
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