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Bcl-2 family proteins: The sentinels of the mitochondrial apoptosis pathway


Wong, W W L; Puthalakath, H (2008). Bcl-2 family proteins: The sentinels of the mitochondrial apoptosis pathway. IUBMB Life, 60(6):390-397.

Abstract

Bcl-2 family members are the arbiters of mitochondrial apo- ptotic pathway, which is conserved through evolution. The stoi- chiometry of pro- versus antiapoptotic Bcl-2 family members in the cell determines whether the cell lives or dies. This fine bal- ance is regulated at the transcriptional or posttranslational level in response to various cellular cues. These signals are transmit- ted through the upstream molecules in the pathway, that is, the BH3-only molecules that results in the activation of the adaptor molecules, Bax and Bak, at the mitochondrial surface ensuing mitochondrial dysfunction and apoptosis. Understanding the activation process offers a great potential in the therapeutic intervention of many diseases such as cancer and autoimmune disorders.

Bcl-2 family members are the arbiters of mitochondrial apo- ptotic pathway, which is conserved through evolution. The stoi- chiometry of pro- versus antiapoptotic Bcl-2 family members in the cell determines whether the cell lives or dies. This fine bal- ance is regulated at the transcriptional or posttranslational level in response to various cellular cues. These signals are transmit- ted through the upstream molecules in the pathway, that is, the BH3-only molecules that results in the activation of the adaptor molecules, Bax and Bak, at the mitochondrial surface ensuing mitochondrial dysfunction and apoptosis. Understanding the activation process offers a great potential in the therapeutic intervention of many diseases such as cancer and autoimmune disorders.

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86 citations in Web of Science®
97 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > Institute of Experimental Immunology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:2008
Deposited On:19 Jun 2012 14:22
Last Modified:05 Apr 2016 15:33
Publisher:Wiley-Blackwell
ISSN:1521-6543
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:10.1002/iub.51
Permanent URL: http://doi.org/10.5167/uzh-58189

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